HCSGD entry for IAPP
1. General information
| Official gene symbol | IAPP |
|---|---|
| Entrez ID | 3375 |
| Gene full name | islet amyloid polypeptide |
| Other gene symbols | DAP IAP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005102 | Receptor binding | TAS | molecular_function |
| GO:0005179 | Hormone activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0019233 | Sensory perception of pain | IEA | biological_process |
| GO:0031018 | Endocrine pancreas development | TAS | biological_process |
| GO:0042755 | Eating behavior | IEA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0045596 | Negative regulation of cell differentiation | IEA | biological_process |
| GO:0045779 | Negative regulation of bone resorption | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4527220280 | 0.2654032066 | 0.9999902473 | 0.9867933362 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1547900320 |
| GSE13712_SHEAR | Down | -0.1292983184 |
| GSE13712_STATIC | Up | 0.0685655220 |
| GSE19018 | Up | 0.0561405834 |
| GSE19899_A1 | Down | -0.1444874132 |
| GSE19899_A2 | Up | 0.1863001162 |
| PubMed_21979375_A1 | Down | -0.0875104031 |
| PubMed_21979375_A2 | Down | -0.0327789710 |
| GSE35957 | Up | 0.0529558581 |
| GSE36640 | Up | 0.0375747414 |
| GSE54402 | Up | 0.0569070776 |
| GSE9593 | Down | -0.0042075024 |
| GSE43922 | Up | 0.0200793388 |
| GSE24585 | Down | -0.0962821076 |
| GSE37065 | Down | -0.0015736161 |
| GSE28863_A1 | Down | -1.2561822199 |
| GSE28863_A2 | Down | -0.0357277184 |
| GSE28863_A3 | Down | -0.0186525559 |
| GSE28863_A4 | Down | -0.0297798732 |
| GSE48662 | Up | 1.5999625158 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018914 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030101 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21251764 | Milk signalling down-regulates the key transcription factor FoxO1 leading to up-regulation of insulin promoter factor-1 which stimulates beta-cell proliferation, insulin secretion as well as coexpression of islet amyloid polypeptide (IAPP) |
| 21251764 | The long-term use of milk may thus increase endoplasmic reticulum (ER) stress and toxic IAPP oligomer formation by overloading the ER with cytotoxic IAPPs thereby promoting beta-cell apoptosis |
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