HCSGD entry for APOA2

1. General information

Official gene symbolAPOA2
Entrez ID336
Gene full nameapolipoprotein A-II
Other gene symbolsApo-AII ApoA-II apoAII
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001523Retinoid metabolic processTASbiological_process
GO:0002526Acute inflammatory responseIEAbiological_process
GO:0002740Negative regulation of cytokine secretion involved in immune responseIDAbiological_process
GO:0005319Lipid transporter activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005543Phospholipid bindingIDAmolecular_function
GO:0005576Extracellular regionNAS TAScellular_component
GO:0005769Early endosomeTAScellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006457Protein foldingIDAbiological_process
GO:0006641Triglyceride metabolic processTASbiological_process
GO:0006656Phosphatidylcholine biosynthetic processIDAbiological_process
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0008035High-density lipoprotein particle bindingIEAmolecular_function
GO:0008203Cholesterol metabolic processIEAbiological_process
GO:0008289Lipid bindingIDAmolecular_function
GO:0009395Phospholipid catabolic processIDAbiological_process
GO:0009749Response to glucoseIDAbiological_process
GO:0010873Positive regulation of cholesterol esterificationIDAbiological_process
GO:0010903Negative regulation of very-low-density lipoprotein particle remodelingIDAbiological_process
GO:0015485Cholesterol bindingIDAmolecular_function
GO:0016032Viral processIEAbiological_process
GO:0017127Cholesterol transporter activityIDAmolecular_function
GO:0018158Protein oxidationIDAbiological_process
GO:0018206Peptidyl-methionine modificationIDAbiological_process
GO:0030300Regulation of intestinal cholesterol absorptionIEAbiological_process
GO:0031100Organ regenerationIEAbiological_process
GO:0031210Phosphatidylcholine bindingIDAmolecular_function
GO:0031647Regulation of protein stabilityIDAbiological_process
GO:0032375Negative regulation of cholesterol transportIMPbiological_process
GO:0033344Cholesterol effluxIDAbiological_process
GO:0033700Phospholipid effluxIDAbiological_process
GO:0034190Apolipoprotein receptor bindingIPImolecular_function
GO:0034361Very-low-density lipoprotein particleIDAcellular_component
GO:0034364High-density lipoprotein particleIDAcellular_component
GO:0034366Spherical high-density lipoprotein particleIDAcellular_component
GO:0034370Triglyceride-rich lipoprotein particle remodelingIDAbiological_process
GO:0034374Low-density lipoprotein particle remodelingIDAbiological_process
GO:0034375High-density lipoprotein particle remodelingIDAbiological_process
GO:0034380High-density lipoprotein particle assemblyIDAbiological_process
GO:0034384High-density lipoprotein particle clearanceIDAbiological_process
GO:0042157Lipoprotein metabolic processTASbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042627ChylomicronIDAcellular_component
GO:0042632Cholesterol homeostasisIDAbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043085Positive regulation of catalytic activityIDAbiological_process
GO:0043627Response to estrogenIEAbiological_process
GO:0043691Reverse cholesterol transportIDAbiological_process
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045416Positive regulation of interleukin-8 biosynthetic processIDAbiological_process
GO:0046340Diacylglycerol catabolic processIDAbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0050995Negative regulation of lipid catabolic processIDAbiological_process
GO:0050996Positive regulation of lipid catabolic processIDAbiological_process
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0055102Lipase inhibitor activityIDAmolecular_function
GO:0060192Negative regulation of lipase activityIDAbiological_process
GO:0060228Phosphatidylcholine-sterol O-acyltransferase activator activityIDAmolecular_function
GO:0060621Negative regulation of cholesterol importIDAbiological_process
GO:0060695Negative regulation of cholesterol transporter activityIDAbiological_process
GO:0070653High-density lipoprotein particle receptor bindingIPImolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.29582265870.91954018080.99506047281.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0887712756
GSE13712_SHEARUp0.0467064264
GSE13712_STATICDown-0.1048654512
GSE19018Up0.0897218348
GSE19899_A1Up0.0781606670
GSE19899_A2Up0.0096425675
PubMed_21979375_A1Down-0.3296473551
PubMed_21979375_A2Up0.2953869005
GSE35957Up0.0979664298
GSE36640Up0.1048141746
GSE54402Down-0.0916424499
GSE9593Up0.0821842959
GSE43922Up0.0280341672
GSE24585Down-0.0523434452
GSE37065Down-0.0399609429
GSE28863_A1Up0.1143075787
GSE28863_A2Up0.1809302221
GSE28863_A3Up0.2716043741
GSE28863_A4Up0.4475412204
GSE48662Down-0.0368697133

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.