HCSGD entry for HTR2A

1. General information

Official gene symbol	HTR2A
Entrez ID	3356
Gene full name	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
Other gene symbols	5-HT2A HTR2
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0001659	Temperature homeostasis	IEA	biological_process
GO:0001965	G-protein alpha-subunit binding	IEA	molecular_function
GO:0004993	Serotonin receptor activity	IDA	molecular_function
GO:0005829	Cytosol	IEA	cellular_component
GO:0005886	Plasma membrane	IDA TAS	cellular_component
GO:0005887	Integral component of plasma membrane	IEA	cellular_component
GO:0005901	Caveola	IEA	cellular_component
GO:0006874	Cellular calcium ion homeostasis	IDA	biological_process
GO:0007202	Activation of phospholipase C activity	IDA	biological_process
GO:0007208	Phospholipase C-activating serotonin receptor signaling pathway	IEA	biological_process
GO:0007210	Serotonin receptor signaling pathway	IMP	biological_process
GO:0007268	Synaptic transmission	TAS	biological_process
GO:0007568	Aging	IEA	biological_process
GO:0007613	Memory	IEA	biological_process
GO:0008144	Drug binding	IDA	molecular_function
GO:0008219	Cell death	IEA	biological_process
GO:0008284	Positive regulation of cell proliferation	IEA	biological_process
GO:0010513	Positive regulation of phosphatidylinositol biosynthetic process	IDA	biological_process
GO:0014059	Regulation of dopamine secretion	IEA	biological_process
GO:0014065	Phosphatidylinositol 3-kinase signaling	IDA	biological_process
GO:0014824	Artery smooth muscle contraction	IEA	biological_process
GO:0014832	Urinary bladder smooth muscle contraction	IEA	biological_process
GO:0016023	Cytoplasmic membrane-bounded vesicle	IEA	cellular_component
GO:0030424	Axon	IEA	cellular_component
GO:0030431	Sleep	IEA	biological_process
GO:0032403	Protein complex binding	IEA	molecular_function
GO:0042493	Response to drug	IDA	biological_process
GO:0043025	Neuronal cell body	IEA	cellular_component
GO:0043198	Dendritic shaft	IEA	cellular_component
GO:0043267	Negative regulation of potassium ion transport	IEA	biological_process
GO:0043406	Positive regulation of MAP kinase activity	IEA	biological_process
GO:0045907	Positive regulation of vasoconstriction	IEA	biological_process
GO:0046883	Regulation of hormone secretion	IEA	biological_process
GO:0048148	Behavioral response to cocaine	IEA	biological_process
GO:0050795	Regulation of behavior	IEA	biological_process
GO:0050965	Detection of temperature stimulus involved in sensory perception of pain	IEA	biological_process
GO:0050966	Detection of mechanical stimulus involved in sensory perception of pain	IEA	biological_process
GO:0051209	Release of sequestered calcium ion into cytosol	IDA IMP	biological_process
GO:0051378	Serotonin binding	IDA	molecular_function
GO:0051967	Negative regulation of synaptic transmission, glutamatergic	IEA	biological_process
GO:0070374	Positive regulation of ERK1 and ERK2 cascade	IDA	biological_process
GO:0070852	Cell body fiber	IEA	cellular_component
GO:0071886	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	IDA	molecular_function

Entries Per Page

Displaying Page of

4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.2109346111	0.3775475818	0.8847969890	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.1407757095
GSE13712_SHEAR	Down	-0.0914690038
GSE13712_STATIC	Up	0.1574000563
GSE19018	Up	0.0537389120
GSE19899_A1	Down	-0.0492050807
GSE19899_A2	Up	0.0135352605
PubMed_21979375_A1	Down	-0.0218462338
PubMed_21979375_A2	Down	-0.0613058197
GSE35957	Up	0.8846567952
GSE36640	Down	-0.0375098821
GSE54402	Down	-0.0576205119
GSE9593	Down	-0.1011967937
GSE43922	Up	0.0350598165
GSE24585	Up	0.1092143318
GSE37065	Up	0.6026618172
GSE28863_A1	Down	-0.3727294429
GSE28863_A2	Down	-0.1994232657
GSE28863_A3	Up	0.1823107043
GSE28863_A4	Down	-0.0690040689
GSE48662	Up	1.1807062543

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results