HCSGD entry for APOA1

1. General information

Official gene symbolAPOA1
Entrez ID335
Gene full nameapolipoprotein A-I
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001523Retinoid metabolic processTASbiological_process
GO:0001540Beta-amyloid bindingIDAmolecular_function
GO:0001932Regulation of protein phosphorylationIEAbiological_process
GO:0001935Endothelial cell proliferationIEAbiological_process
GO:0002576Platelet degranulationTASbiological_process
GO:0002740Negative regulation of cytokine secretion involved in immune responseIDAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005543Phospholipid bindingIDAmolecular_function
GO:0005548Phospholipid transporter activityIEAmolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0005615Extracellular spaceIDA ISScellular_component
GO:0005634NucleusIEAcellular_component
GO:0005769Early endosomeTAScellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006656Phosphatidylcholine biosynthetic processIDAbiological_process
GO:0006695Cholesterol biosynthetic processIEAbiological_process
GO:0006869Lipid transportIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0008035High-density lipoprotein particle bindingIEAmolecular_function
GO:0008203Cholesterol metabolic processIMPbiological_process
GO:0008211Glucocorticoid metabolic processIEAbiological_process
GO:0008289Lipid bindingIEAmolecular_function
GO:0010804Negative regulation of tumor necrosis factor-mediated signaling pathwayIDAbiological_process
GO:0010873Positive regulation of cholesterol esterificationIDAbiological_process
GO:0010903Negative regulation of very-low-density lipoprotein particle remodelingIDAbiological_process
GO:0014012Peripheral nervous system axon regenerationIEAbiological_process
GO:0015485Cholesterol bindingIDAmolecular_function
GO:0017127Cholesterol transporter activityIDA IMPmolecular_function
GO:0018158Protein oxidationIDAbiological_process
GO:0018206Peptidyl-methionine modificationIDAbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0019915Lipid storageIEAbiological_process
GO:0030139Endocytic vesicleIDAcellular_component
GO:0030168Platelet activationTASbiological_process
GO:0030300Regulation of intestinal cholesterol absorptionIEAbiological_process
GO:0030301Cholesterol transportIDAbiological_process
GO:0030325Adrenal gland developmentIEAbiological_process
GO:0031100Organ regenerationIEAbiological_process
GO:0031410Cytoplasmic vesicleIDAcellular_component
GO:0032489Regulation of Cdc42 protein signal transductionIDAbiological_process
GO:0033344Cholesterol effluxIDAbiological_process
GO:0033700Phospholipid effluxIDAbiological_process
GO:0034115Negative regulation of heterotypic cell-cell adhesionIDAbiological_process
GO:0034190Apolipoprotein receptor bindingIPImolecular_function
GO:0034191Apolipoprotein A-I receptor bindingIPImolecular_function
GO:0034361Very-low-density lipoprotein particleIDAcellular_component
GO:0034364High-density lipoprotein particleIDAcellular_component
GO:0034366Spherical high-density lipoprotein particleIDAcellular_component
GO:0034375High-density lipoprotein particle remodelingICbiological_process
GO:0034380High-density lipoprotein particle assemblyIDAbiological_process
GO:0034384High-density lipoprotein particle clearanceICbiological_process
GO:0034774Secretory granule lumenTAScellular_component
GO:0042157Lipoprotein metabolic processIEA TASbiological_process
GO:0042158Lipoprotein biosynthetic processIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042632Cholesterol homeostasisIDA IMPbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043534Blood vessel endothelial cell migrationIEAbiological_process
GO:0043627Response to estrogenIEAbiological_process
GO:0043691Reverse cholesterol transportIMPbiological_process
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0050713Negative regulation of interleukin-1 beta secretionIDAbiological_process
GO:0050728Negative regulation of inflammatory responseIDAbiological_process
GO:0050821Protein stabilizationIDAbiological_process
GO:0051345Positive regulation of hydrolase activityIDAbiological_process
GO:0051347Positive regulation of transferase activityIEAbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0055091Phospholipid homeostasisIDAbiological_process
GO:0055102Lipase inhibitor activityIEAmolecular_function
GO:0060192Negative regulation of lipase activityIEAbiological_process
GO:0060228Phosphatidylcholine-sterol O-acyltransferase activator activityIDAmolecular_function
GO:0060354Negative regulation of cell adhesion molecule productionIDAbiological_process
GO:0060761Negative regulation of response to cytokine stimulusIDAbiological_process
GO:0070328Triglyceride homeostasisIDAbiological_process
GO:0070508Cholesterol importIMPbiological_process
GO:0070653High-density lipoprotein particle receptor bindingIPImolecular_function
GO:0071682Endocytic vesicle lumenTAScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.39685129360.92529572960.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1675570964
GSE13712_SHEARDown-0.1032330490
GSE13712_STATICDown-0.0701219792
GSE19018Down-0.0699331227
GSE19899_A1Up0.0189015562
GSE19899_A2Up0.1414195932
PubMed_21979375_A1Up0.2277383310
PubMed_21979375_A2Up0.1255319038
GSE35957Up0.1851284773
GSE36640Up0.0227261177
GSE54402Up0.2589394750
GSE9593Up0.0706189773
GSE43922Up0.1096563972
GSE24585Down-0.1640419724
GSE37065Down-0.0385029992
GSE28863_A1Up0.0702206729
GSE28863_A2Down-0.0589710189
GSE28863_A3Up0.3702240510
GSE28863_A4Up0.0621081850
GSE48662Down-0.1289111246

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26363928Apolipoprotein A-I (apoA-I) is the principal protein behind the beneficial functions of HDL, which include potent anti-oxidant, anti-inflammatory, and anti-atherosclerotic activities in blood
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