HCSGD entry for APLP2
1. General information
| Official gene symbol | APLP2 |
|---|---|
| Entrez ID | 334 |
| Gene full name | amyloid beta (A4) precursor-like protein 2 |
| Other gene symbols | APLP-2 APPH APPL2 CDEBP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001967 | Suckling behavior | IEA | biological_process |
| GO:0003677 | DNA binding | NAS | molecular_function |
| GO:0004867 | Serine-type endopeptidase inhibitor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006878 | Cellular copper ion homeostasis | IEA | biological_process |
| GO:0007176 | Regulation of epidermal growth factor-activated receptor activity | IEA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | NAS | biological_process |
| GO:0007617 | Mating behavior | IEA | biological_process |
| GO:0007626 | Locomotory behavior | IEA | biological_process |
| GO:0008201 | Heparin binding | IEA | molecular_function |
| GO:0008203 | Cholesterol metabolic process | IEA | biological_process |
| GO:0009790 | Embryo development | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA NAS | cellular_component |
| GO:0030198 | Extracellular matrix organization | IEA | biological_process |
| GO:0030900 | Forebrain development | IEA | biological_process |
| GO:0030901 | Midbrain development | IEA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0043393 | Regulation of protein binding | IEA | biological_process |
| GO:0046914 | Transition metal ion binding | IEA | molecular_function |
| GO:0050885 | Neuromuscular process controlling balance | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0184350861 | 0.9845935375 | 0.3321217659 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5848721345 |
| GSE13712_SHEAR | Down | -0.0374208157 |
| GSE13712_STATIC | Down | -0.0584864601 |
| GSE19018 | Up | 0.2202962728 |
| GSE19899_A1 | Down | -0.0988684428 |
| GSE19899_A2 | Up | 0.7098452326 |
| PubMed_21979375_A1 | Up | 0.2915035660 |
| PubMed_21979375_A2 | Up | 0.5389753254 |
| GSE35957 | Down | -0.3326518700 |
| GSE36640 | Up | 0.7171993776 |
| GSE54402 | Down | -0.0375324282 |
| GSE9593 | Up | 0.1364824997 |
| GSE43922 | Up | 0.2168537729 |
| GSE24585 | Up | 0.5446690265 |
| GSE37065 | Up | 0.2131574364 |
| GSE28863_A1 | Up | 0.2009254734 |
| GSE28863_A2 | Up | 0.2190234916 |
| GSE28863_A3 | Up | 0.2218836870 |
| GSE28863_A4 | Up | 0.3128319600 |
| GSE48662 | Up | 0.2592407905 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | MIRT025806 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025806 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-346 | MIMAT0000773 | MIRT042713 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044252 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048819 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052735 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
