HCSGD entry for APLP1
1. General information
| Official gene symbol | APLP1 |
|---|---|
| Entrez ID | 333 |
| Gene full name | amyloid beta (A4) precursor-like protein 1 |
| Other gene symbols | APLP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005604 | Basement membrane | TAS | cellular_component |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006378 | MRNA polyadenylation | IEA | biological_process |
| GO:0006417 | Regulation of translation | IEA | biological_process |
| GO:0006897 | Endocytosis | IEA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007193 | Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | IC | biological_process |
| GO:0007399 | Nervous system development | TAS | biological_process |
| GO:0008201 | Heparin binding | IEA | molecular_function |
| GO:0009887 | Organ morphogenesis | TAS | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030198 | Extracellular matrix organization | IEA | biological_process |
| GO:0030818 | Negative regulation of cAMP biosynthetic process | IDA | biological_process |
| GO:0030900 | Forebrain development | IEA | biological_process |
| GO:0031694 | Alpha-2A adrenergic receptor binding | IPI | molecular_function |
| GO:0031695 | Alpha-2B adrenergic receptor binding | IPI | molecular_function |
| GO:0031696 | Alpha-2C adrenergic receptor binding | IPI | molecular_function |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0046914 | Transition metal ion binding | IEA | molecular_function |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0071874 | Cellular response to norepinephrine stimulus | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0120677672 | 0.6347406102 | 0.2745338807 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0755809295 |
| GSE13712_SHEAR | Down | -1.2165459476 |
| GSE13712_STATIC | Down | -0.4684849024 |
| GSE19018 | Up | 0.5193069430 |
| GSE19899_A1 | Up | 0.5851391890 |
| GSE19899_A2 | Up | 0.9456697568 |
| PubMed_21979375_A1 | Up | 0.5363454587 |
| PubMed_21979375_A2 | Up | 1.0807157024 |
| GSE35957 | Down | -0.5224234077 |
| GSE36640 | Up | 1.2470832423 |
| GSE54402 | Up | 0.2224883213 |
| GSE9593 | Down | -0.4503434654 |
| GSE43922 | Up | 0.4441591509 |
| GSE24585 | Up | 0.6362443454 |
| GSE37065 | Up | 0.0441380154 |
| GSE28863_A1 | Down | -0.0055321807 |
| GSE28863_A2 | Down | -0.0617237595 |
| GSE28863_A3 | Down | -0.2264583534 |
| GSE28863_A4 | Down | -0.1118266686 |
| GSE48662 | Up | 0.7670003326 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016721 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-484 | MIMAT0002174 | MIRT041986 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17533371 | Amyloid-beta precursor-like protein APLP1 is a novel p53 transcriptional target gene that augments neuroblastoma cell death upon genotoxic stress |
| 17533371 | In particular, the amyloid-beta precursor-like protein 1 (APLP1) is induced in senescent cells in a p53-dependent manner |
| 17533371 | APLP1 was confirmed to be a novel transcriptional target of p53 by in vivo and in vitro characterization of a p53 responsive element found in the first intron of the APLP1 gene locus |
| 17533371 | APLP1 knockdown experiments demonstrate that APLP1 is required for the proliferation of fibroblastic and epithelial cells |
| 17533371 | Moreover, depletion of APLP1 expression diminishes stress-induced apoptosis of neural cells, whereas ectopic APLP1 expression augments apoptosis |
| 17533371 | Based on these data, a mechanism is proposed whereby p53-dependent induction of APLP1 is involved in neural cell death, and which may exacerbate neuronal cell loss in some acute or chronic neurodegenerative disorders |
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