HCSGD entry for HSP90AB1

1. General information

Official gene symbolHSP90AB1
Entrez ID3326
Gene full nameheat shock protein 90kDa alpha (cytosolic), class B member 1
Other gene symbolsD6S182 HSP84 HSP90B HSPC2 HSPCB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001890Placenta developmentIEAbiological_process
GO:0002134UTP bindingIEAmolecular_function
GO:0002135CTP bindingIEAmolecular_function
GO:0003725Double-stranded RNA bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006457Protein foldingIEAbiological_process
GO:0006950Response to stressIEAbiological_process
GO:0006986Response to unfolded proteinNASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008180COP9 signalosomeIDAcellular_component
GO:0009651Response to salt stressIEAbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0016234Inclusion bodyIEAcellular_component
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0017098Sulfonylurea receptor bindingIEAmolecular_function
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0030235Nitric-oxide synthase regulator activityISSmolecular_function
GO:0030911TPR domain bindingISSmolecular_function
GO:0031526Brush border membraneIEAcellular_component
GO:0032092Positive regulation of protein bindingIEAbiological_process
GO:0032435Negative regulation of proteasomal ubiquitin-dependent protein catabolic processIMPbiological_process
GO:0032564DATP bindingIEAmolecular_function
GO:0033160Positive regulation of protein import into nucleus, translocationIEAbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0042470MelanosomeIEAcellular_component
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0044325Ion channel bindingIEAmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045429Positive regulation of nitric oxide biosynthetic processISSbiological_process
GO:0045793Positive regulation of cell sizeIEAbiological_process
GO:0051082Unfolded protein bindingIEAmolecular_function
GO:0060334Regulation of interferon-gamma-mediated signaling pathwayIMPbiological_process
GO:0060338Regulation of type I interferon-mediated signaling pathwayIMPbiological_process
GO:0071353Cellular response to interleukin-4IEAbiological_process
GO:0071407Cellular response to organic cyclic compoundIEAbiological_process
GO:0071902Positive regulation of protein serine/threonine kinase activityIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.42214258580.46435022230.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4598737952
GSE13712_SHEARDown-0.0850618808
GSE13712_STATICUp0.0266394192
GSE19018Down-0.6841755464
GSE19899_A1Up0.0333317681
GSE19899_A2Up0.1534188473
PubMed_21979375_A1Up0.1388542494
PubMed_21979375_A2Down-0.6344531695
GSE35957Down-0.3070652591
GSE36640Down-0.0638536873
GSE54402Up0.1774462847
GSE9593Up0.1926718646
GSE43922Up0.1173585828
GSE24585Down-0.0469201340
GSE37065Down-0.0020946822
GSE28863_A1Up0.0872985563
GSE28863_A2Down-0.0445174589
GSE28863_A3Up0.2979826630
GSE28863_A4Down-0.0623744912
GSE48662Down-0.0633015698

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GeldanamycinDB02424 EXPT01571
9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-AmineDB02754 EXPT02694
RadicicolDB03758 EXPT02763
CNF1010DB05134 -
SNX-5422DB06070 -
4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOLDB07594 -
8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINEDB07877 -
4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOLDB08045 -
(5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONEDB08153 -
(5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONEDB08292 -
(5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONEDB08293 -
(5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONEDB08346 -
METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATEDB08464 -
2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATEDB08465 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016366ProteomicsFunctional MTI (Weak)21512034
hsa-miR-877-3pMIMAT0004950MIRT037004CLASHFunctional MTI (Weak)23622248
hsa-miR-455-3pMIMAT0004784MIRT037860CLASHFunctional MTI (Weak)23622248
hsa-miR-296-3pMIMAT0004679MIRT038357CLASHFunctional MTI (Weak)23622248
hsa-miR-93-3pMIMAT0004509MIRT038803CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT039893CLASHFunctional MTI (Weak)23622248
hsa-miR-501-5pMIMAT0002872MIRT041138CLASHFunctional MTI (Weak)23622248
hsa-miR-181d-5pMIMAT0002821MIRT041164CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041702CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044757CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT044926CLASHFunctional MTI (Weak)23622248
hsa-miR-15b-5pMIMAT0000417MIRT046508CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049288CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.