HCSGD entry for BIRC5
1. General information
| Official gene symbol | BIRC5 |
|---|---|
| Entrez ID | 332 |
| Gene full name | baculoviral IAP repeat containing 5 |
| Other gene symbols | API4 EPR-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | IDA | biological_process |
| GO:0000226 | Microtubule cytoskeleton organization | IEA | biological_process |
| GO:0000228 | Nuclear chromosome | IDA | cellular_component |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000775 | Chromosome, centromeric region | IDA | cellular_component |
| GO:0000777 | Condensed chromosome kinetochore | IDA | cellular_component |
| GO:0000910 | Cytokinesis | IMP | biological_process |
| GO:0004869 | Cysteine-type endopeptidase inhibitor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005814 | Centriole | IDA | cellular_component |
| GO:0005819 | Spindle | IEA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0005874 | Microtubule | IEA | cellular_component |
| GO:0005876 | Spindle microtubule | IDA | cellular_component |
| GO:0005881 | Cytoplasmic microtubule | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007059 | Chromosome segregation | IEA | biological_process |
| GO:0007067 | Mitosis | IEA TAS | biological_process |
| GO:0008017 | Microtubule binding | IDA TAS | molecular_function |
| GO:0008270 | Zinc ion binding | IDA NAS | molecular_function |
| GO:0008284 | Positive regulation of cell proliferation | TAS | biological_process |
| GO:0008536 | Ran GTPase binding | IPI | molecular_function |
| GO:0009790 | Embryo development | IEA | biological_process |
| GO:0015631 | Tubulin binding | IDA | molecular_function |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030496 | Midbody | IDA | cellular_component |
| GO:0031021 | Interphase microtubule organizing center | IDA | cellular_component |
| GO:0031503 | Protein complex localization | IMP | biological_process |
| GO:0031536 | Positive regulation of exit from mitosis | IMP | biological_process |
| GO:0031577 | Spindle checkpoint | IMP | biological_process |
| GO:0032133 | Chromosome passenger complex | IPI | cellular_component |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0042803 | Protein homodimerization activity | IDA IPI | molecular_function |
| GO:0043027 | Cysteine-type endopeptidase inhibitor activity involved in apoptotic process | IMP | molecular_function |
| GO:0043066 | Negative regulation of apoptotic process | IDA IMP | biological_process |
| GO:0043154 | Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | IDA IMP | biological_process |
| GO:0043524 | Negative regulation of neuron apoptotic process | IEA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0045931 | Positive regulation of mitotic cell cycle | IMP | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0046982 | Protein heterodimerization activity | IDA | molecular_function |
| GO:0048037 | Cofactor binding | IDA | molecular_function |
| GO:0050897 | Cobalt ion binding | NAS | molecular_function |
| GO:0051087 | Chaperone binding | IPI | molecular_function |
| GO:0051301 | Cell division | IMP | biological_process |
| GO:0051303 | Establishment of chromosome localization | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9808026861 | 0.0000108279 | 0.9999902473 | 0.0069833333 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.8452121636 |
| GSE13712_SHEAR | Down | -0.1042934902 |
| GSE13712_STATIC | Down | -0.5699020664 |
| GSE19018 | Up | 0.2548380613 |
| GSE19899_A1 | Down | -1.4156488162 |
| GSE19899_A2 | Down | -4.9809694407 |
| PubMed_21979375_A1 | Down | -5.0310026700 |
| PubMed_21979375_A2 | Down | -6.0577164902 |
| GSE35957 | Down | -3.4663407100 |
| GSE36640 | Down | -4.6768478904 |
| GSE54402 | Down | -1.2681507996 |
| GSE9593 | Down | -1.2685097412 |
| GSE43922 | Down | -0.6378301848 |
| GSE24585 | Down | -0.0215923134 |
| GSE37065 | Down | -0.2078895241 |
| GSE28863_A1 | Down | -0.6139325075 |
| GSE28863_A2 | Up | 0.1177852757 |
| GSE28863_A3 | Down | -0.7495285526 |
| GSE28863_A4 | Up | 0.3492821266 |
| GSE48662 | Down | -2.9306522189 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| LY2181308 | DB05141 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-203a | MIMAT0000264 | MIRT006256 | Luciferase reporter assay | Functional MTI | 22306317 |
| hsa-miR-542-3p | MIMAT0003389 | MIRT005363 | Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 20728447 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT007304 | Luciferase reporter assay | Functional MTI | 23232114 |
| hsa-miR-425-5p | MIMAT0003393 | MIRT016656 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT025591 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027310 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1301-3p | MIMAT0005797 | MIRT036054 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036530 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041728 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045690 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047940 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048806 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052024 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-708-5p | MIMAT0004926 | 1 | hsa-miR-708 | 21852381 | |||
| hsa-miR-708-5p | MIMAT0004926 | 2 | hsa-miR-708 | 21852381 | |||
| hsa-miR-708-5p | MIMAT0004926 | 3 | hsa-miR-708 | 21852381 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26159786 | Survivin (BIRC5) is highly expressed in the vast majority of human cancers and is associated with chemotherapy resistance, increased tumor recurrence and shortened patient survival, making it an attractive therapeutic target |
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