HCSGD entry for HSD17B4

1. General information

Official gene symbolHSD17B4
Entrez ID3295
Gene full namehydroxysteroid (17-beta) dehydrogenase 4
Other gene symbolsDBP MFE-2 MPF-2 PRLTS1 SDR8C1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000038Very long-chain fatty acid metabolic processIEAbiological_process
GO:00038573-hydroxyacyl-CoA dehydrogenase activityIDA IMP TASmolecular_function
GO:0005102Receptor bindingIPImolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005777PeroxisomeIDA IEA NAScellular_component
GO:0005778Peroxisomal membraneIDAcellular_component
GO:0005782Peroxisomal matrixTAScellular_component
GO:0006635Fatty acid beta-oxidationIDAbiological_process
GO:0006699Bile acid biosynthetic processTASbiological_process
GO:0008152Metabolic processIDA IMPbiological_process
GO:0008206Bile acid metabolic processTASbiological_process
GO:0008209Androgen metabolic processIDAbiological_process
GO:0008210Estrogen metabolic processIDAbiological_process
GO:0016491Oxidoreductase activityIEAmolecular_function
GO:0016508Long-chain-enoyl-CoA hydratase activityIDA TASmolecular_function
GO:0016853Isomerase activityIEAmolecular_function
GO:0032934Sterol bindingIEAmolecular_function
GO:0033540Fatty acid beta-oxidation using acyl-CoA oxidaseTASbiological_process
GO:0033559Unsaturated fatty acid metabolic processTASbiological_process
GO:00339893alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activityTASmolecular_function
GO:0036109Alpha-linolenic acid metabolic processTASbiological_process
GO:0036111Very long-chain fatty-acyl-CoA metabolic processIDAbiological_process
GO:0036112Medium-chain fatty-acyl-CoA metabolic processIDAbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:004459417-beta-hydroxysteroid dehydrogenase (NAD+) activityIDAmolecular_function
GO:0055114Oxidation-reduction processIDA IMPbiological_process
GO:0060009Sertoli cell developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.98706975420.05464695870.99999024730.4409450031

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0177782549
GSE13712_SHEARDown-0.0257227281
GSE13712_STATICDown-0.1935468844
GSE19018Down-0.0762926043
GSE19899_A1Down-0.4231017294
GSE19899_A2Down-0.4987033132
PubMed_21979375_A1Down-0.4406618772
PubMed_21979375_A2Down-0.3637138631
GSE35957Down-0.0404565433
GSE36640Down-0.0946178184
GSE54402Down-0.0698693909
GSE9593Up0.0117942179
GSE43922Down-0.4900271481
GSE24585Down-0.1064623979
GSE37065Down-0.1052901290
GSE28863_A1Down-0.0244044684
GSE28863_A2Up0.2774702893
GSE28863_A3Down-0.2917190624
GSE28863_A4Down-0.0742111348
GSE48662Down-0.5048307711

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527
3r-Hydroxydecanoyl-CoaDB03192 EXPT01712

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-484MIMAT0002174MIRT042372CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043174CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.