HCSGD entry for HSD11B1

1. General information

Official gene symbolHSD11B1
Entrez ID3290
Gene full namehydroxysteroid (11-beta) dehydrogenase 1
Other gene symbols11-DH 11-beta-HSD1 CORTRD2 HDL HSD11 HSD11B HSD11L SDR26C1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:000384511-beta-hydroxysteroid dehydrogenase [NAD(P)] activityTASmolecular_function
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006704Glucocorticoid biosynthetic processTASbiological_process
GO:0008202Steroid metabolic processTASbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0030324Lung developmentIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:007052411-beta-hydroxysteroid dehydrogenase (NADP+) activityIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00033882450.78659473800.04954555561.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up2.8626854567
GSE13712_SHEARUp0.0976868724
GSE13712_STATICUp0.1917944440
GSE19018Down-0.3795407625
GSE19899_A1Up0.6409274718
GSE19899_A2Up2.1243650640
PubMed_21979375_A1Up1.6176308745
PubMed_21979375_A2Up3.3539741436
GSE35957Down-0.1089425849
GSE36640Down-0.2630851229
GSE54402Down-0.6213564168
GSE9593Up1.6588419656
GSE43922Up1.3434827456
GSE24585Up0.0020095396
GSE37065Up1.7001261083
GSE28863_A1Up0.3648483516
GSE28863_A2Up0.5723153262
GSE28863_A3Up0.0423639182
GSE28863_A4Down-0.3195262798
GSE48662Up0.6876658332

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527
PrednisoneDB00635 APRD00340
CarbenoxoloneDB02329 EXPT00848
2'-Monophosphoadenosine 5'-DiphosphoriboseDB03461 EXPT02293
2-(N-Morpholino)-Ethanesulfonic AcidDB03814 EXPT02154
(11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONEDB04652 -
INCB13739DB05064 -
(3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanoneDB06992 -
(5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-hydroxy-1-methylethyl)-5-methyl-1,3-thiazol-4(5H)-oneDB07017 -
(2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-(4-nitrophenyl)piperazineDB07049 -
2-(6-{[(3-chloro-2-methylphenyl)sulfonyl]amino}pyridin-2-yl)-N,N-diethylacetamideDB07056 -
(5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5-(trifluoromethyl)-1,3-thiazol-4(5H)-oneDB07310 -
N-{1-[(1-carbamoylcyclopropyl)methyl]piperidin-4-yl}-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamideDB07316 -
N-cyclopropyl-N-(trans-4-pyridin-3-ylcyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamideDB07619 -
1-{[(3R)-3-methyl-4-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamideDB07624 -
(5S)-2-(cyclooctylamino)-5-methyl-5-propyl-1,3-thiazol-4(5H)-oneDB07866 -
2-(2-CHLORO-4-FLUOROPHENOXY)-2-METHYL-N-[(1R,2S,3S,5S,7S)-5-(METHYLSULFONYL)-2-ADAMANTYL]PROPANAMIDEDB08277 -
(1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDEDB08280 -
(5R)-2-[(2-fluorophenyl)amino]-5-(1-methylethyl)-1,3-thiazol-4(5H)-oneDB08771 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018628MicroarrayFunctional MTI (Weak)18185580
hsa-miR-26b-5pMIMAT0000083MIRT030055MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.