HCSGD entry for BIRC2

1. General information

Official gene symbolBIRC2
Entrez ID329
Gene full namebaculoviral IAP repeat containing 2
Other gene symbolsAPI1 HIAP2 Hiap-2 MIHB RNF48 c-IAP1 cIAP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000209Protein polyubiquitinationIDAbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001741XY bodyIEAcellular_component
GO:0001890Placenta developmentIEAbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0003713Transcription coactivator activityIMPmolecular_function
GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006921Cellular component disassembly involved in execution phase of apoptosisTASbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0008270Zinc ion bindingIDA IEAmolecular_function
GO:0009898Cytoplasmic side of plasma membraneIEA ISScellular_component
GO:0034121Regulation of toll-like receptor signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0035631CD40 receptor complexIEA ISScellular_component
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038061NIK/NF-kappaB signalingTASbiological_process
GO:0039535Regulation of RIG-I signaling pathwayTASbiological_process
GO:0042127Regulation of cell proliferationTASbiological_process
GO:0042981Regulation of apoptotic processIEA IMPbiological_process
GO:0043066Negative regulation of apoptotic processIDA TASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEPbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045088Regulation of innate immune responseTASbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045471Response to ethanolIEAbiological_process
GO:0045595Regulation of cell differentiationTASbiological_process
GO:0047485Protein N-terminus bindingIPImolecular_function
GO:0050727Regulation of inflammatory responseTASbiological_process
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0051591Response to cAMPIEAbiological_process
GO:0051726Regulation of cell cycleIDAbiological_process
GO:0060544Regulation of necroptotic processIMPbiological_process
GO:0070266Necroptotic processIEAbiological_process
GO:0070424Regulation of nucleotide-binding oligomerization domain containing signaling pathwayTASbiological_process
GO:1902523Positive regulation of protein K63-linked ubiquitinationIDAbiological_process
GO:1902524Positive regulation of protein K48-linked ubiquitinationIDAbiological_process
GO:1902527Positive regulation of protein monoubiquitinationIDAbiological_process
GO:2000116Regulation of cysteine-type endopeptidase activityTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.10156143380.66662490030.66365404671.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0300007042
GSE13712_SHEARUp0.2259317868
GSE13712_STATICUp0.1101340401
GSE19018Down-0.2908777776
GSE19899_A1Up0.0265574233
GSE19899_A2Up0.1868993399
PubMed_21979375_A1Up0.4780393402
PubMed_21979375_A2Up0.1562044854
GSE35957Up0.0098191933
GSE36640Up0.5775657795
GSE54402Up0.5988617094
GSE9593Down-0.2750478375
GSE43922Up0.2594015001
GSE24585Up0.3203612968
GSE37065Up0.2898036836
GSE28863_A1Down-0.3326017423
GSE28863_A2Up0.0095616956
GSE28863_A3Down-0.5597414662
GSE28863_A4Up0.3383771512
GSE48662Down-0.3871158673

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-204-5pMIMAT0000265MIRT005820Immunoblot//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI21282569
hsa-miR-124-3pMIMAT0000422MIRT022141MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.