HCSGD entry for PRMT1

1. General information

Official gene symbolPRMT1
Entrez ID3276
Gene full nameprotein arginine methyltransferase 1
Other gene symbolsANM1 HCP1 HRMT1L2 IR1B4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001701In utero embryonic developmentIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmIEAcellular_component
GO:0005737CytoplasmIEA TAScellular_component
GO:0005829CytosolIEAcellular_component
GO:0006479Protein methylationIEA TASbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0008168Methyltransferase activityIEA TASmolecular_function
GO:0008170N-methyltransferase activityIDA IMPmolecular_function
GO:0008276Protein methyltransferase activityIEAmolecular_function
GO:0008469Histone-arginine N-methyltransferase activityIEAmolecular_function
GO:0016275[cytochrome c]-arginine N-methyltransferase activityIEAmolecular_function
GO:0016571Histone methylationIDAbiological_process
GO:0018216Peptidyl-arginine methylationIDAbiological_process
GO:0030519SnoRNP bindingIEAmolecular_function
GO:0031175Neuron projection developmentIMPbiological_process
GO:0035241Protein-arginine omega-N monomethyltransferase activityIEAmolecular_function
GO:0035242Protein-arginine omega-N asymmetric methyltransferase activityIEAmolecular_function
GO:0035246Peptidyl-arginine N-methylationIDAbiological_process
GO:0042054Histone methyltransferase activityIDAmolecular_function
GO:0042802Identical protein bindingIEA IPImolecular_function
GO:0043234Protein complexIEAcellular_component
GO:0043985Histone H4-R3 methylationIDAbiological_process
GO:0044020Histone methyltransferase activity (H4-R3 specific)IDAmolecular_function
GO:0045653Negative regulation of megakaryocyte differentiationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.88513265830.11259345390.99999024730.6428867679

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0474757878
GSE13712_SHEARDown-0.0779050100
GSE13712_STATICUp0.0493269705
GSE19018Down-0.0739352523
GSE19899_A1Down-0.1605883069
GSE19899_A2Up0.0179995810
PubMed_21979375_A1Up0.5351755349
PubMed_21979375_A2Down-0.2179685497
GSE35957Down-0.3434099123
GSE36640Down-0.5523742799
GSE54402Up0.1521336565
GSE9593Down-0.1414640314
GSE43922Down-0.0272857912
GSE24585Down-0.8725110302
GSE37065Down-0.1847763108
GSE28863_A1Down-0.1439539701
GSE28863_A2Down-0.2499431252
GSE28863_A3Up0.1136196027
GSE28863_A4Up0.1370471503
GSE48662Up0.5499401596

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL1088977CHEMBL55249Q99873
CHEMBL1797553CHEMBL55249Q99873
CHEMBL1271164CHEMBL55249Q99873
CHEMBL1797441CHEMBL55249Q99873
CHEMBL440550CHEMBL55249Q99873
CHEMBL1795366CHEMBL55249Q99873
CHEMBL1797556CHEMBL55249Q99873
CHEMBL1269351CHEMBL55249Q99873
CHEMBL221047CHEMBL55249Q99873
CHEMBL1090536CHEMBL55249Q99873
CHEMBL1088868CHEMBL55249Q99873
CHEMBL1797551CHEMBL55249Q99873
CHEMBL142304CHEMBL55249Q99873
CHEMBL409290CHEMBL55249Q99873
CHEMBL1797445CHEMBL55249Q99873
CHEMBL1092740CHEMBL55249Q99873
CHEMBL1797447CHEMBL55249Q99873
CHEMBL1797453CHEMBL55249Q99873
CHEMBL1093966CHEMBL55249Q99873
CHEMBL1797448CHEMBL55249Q99873
CHEMBL1797443CHEMBL55249Q99873
CHEMBL1797454CHEMBL55249Q99873
CHEMBL1797446CHEMBL55249Q99873
CHEMBL221047CHEMBL55248Q99873
CHEMBL1092740CHEMBL55248Q99873
CHEMBL227988CHEMBL55248Q99873
CHEMBL409290CHEMBL55248Q99873
CHEMBL177756CHEMBL55248Q99873
CHEMBL228132CHEMBL55248Q99873
CHEMBL142304CHEMBL55248Q99873
CHEMBL376503CHEMBL55248Q99873
CHEMBL142304CHEMBL55248Q99873
CHEMBL142304CHEMBL55248Q99873
CHEMBL222509CHEMBL55248Q99873
CHEMBL375405CHEMBL55248Q99873
CHEMBL227298CHEMBL55248Q99873
CHEMBL441718CHEMBL55248Q99873
CHEMBL227725CHEMBL55248Q99873
CHEMBL220275CHEMBL55248Q99873
CHEMBL1271164CHEMBL55248Q99873
CHEMBL1092740CHEMBL55248Q99873
CHEMBL221047CHEMBL55248Q99873
CHEMBL61824CHEMBL55248Q99873
CHEMBL390383CHEMBL55248Q99873
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  • Drugs

Name

Drug

Accession number

S-Adenosyl-L-HomocysteineDB01752 EXPT02842

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30a-5pMIMAT0000087MIRT028512ProteomicsFunctional MTI (Weak)18668040
hsa-miR-877-3pMIMAT0004950MIRT037074CLASHFunctional MTI (Weak)23622248
hsa-miR-378a-5pMIMAT0000731MIRT043993CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26813495The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1
26813495Although the involvement of protein arginine methyltransferase 1 (PRMT1) in tumorigenesis has been reported, its roles in breast cancer progression and metastasis has not been elucidated
26813495We showed that the EMT program induced by PRMT1 endowed the human mammary epithelial cells with cancer stem cell properties
26813495Moreover, PRMT1 promoted the migratory and invasive behaviors in breast cancer cells
26813495We also demonstrated that abrogation of PRMT1 expression in breast cancer cells abated metastasis in vivo in mouse model
26813495This finding points to the potent value of PRMT1 as a dual therapeutic target for preventing metastasis and for inhibiting cancer cell growth in malignant breast cancer patients
19596784We have shown that loss of PRMT1 induces growth arrest in normal human cells but has no effect on cell proliferation in cancer cells, suggesting that PRMT1 may control cell proliferation in a cell type-specific manner
18676353When the expression of protein arginine methyltransferases (PRMTs), namely PRMT1, PRMT4, PRMT5 and PRMT6 was examined, a significant reduction was found in replicatively senescent cells as well as their catalytic activities against histone mixtures compared with the young cells
18676353Furthermore, when the endogenous level of arginine-dimethylated proteins was determined, asymmetric modification (the product of type I PRMTs including PRMT1, PRMT4 and PRMT6) was markedly down-regulated
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