HCSGD entry for AIRE

1. General information

Official gene symbolAIRE
Entrez ID326
Gene full nameautoimmune regulator
Other gene symbolsAIRE1 APECED APS1 APSI PGA1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003682Chromatin bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA NAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIDAbiological_process
GO:0006955Immune responseTASbiological_process
GO:0006959Humoral immune responseIEAbiological_process
GO:0008270Zinc ion bindingIDA IEAmolecular_function
GO:0015629Actin cytoskeletonIDAcellular_component
GO:0042393Histone bindingIDAmolecular_function
GO:0042802Identical protein bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045182Translation regulator activityIEAmolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.28499598040.81009753810.98405030831.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0855178989
GSE13712_SHEARUp0.5111513464
GSE13712_STATICUp0.1706470916
GSE19018Up0.1115276568
GSE19899_A1Up0.0014734048
GSE19899_A2Down-0.2320661895
PubMed_21979375_A1Down0.0000000000
PubMed_21979375_A2Down-0.2534327216
GSE35957Down-0.1606104529
GSE36640Up0.0329117619
GSE54402Up0.0227414335
GSE9593Up0.1151939089
GSE43922Up0.1443472264
GSE24585Down-0.0370458585
GSE37065Down-0.0549318277
GSE28863_A1Down-0.0351669567
GSE28863_A2Up0.1026613079
GSE28863_A3Up0.3808391750
GSE28863_A4Up0.2665554180
GSE48662Up0.3019584016

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.