HCSGD entry for HPN


1. General information

Official gene symbolHPN
Entrez ID3249
Gene full namehepsin
Other gene symbolsTMPRSS1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004252Serine-type endopeptidase activityIDA IEAmolecular_function
GO:0005044Scavenger receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005789Endoplasmic reticulum membraneIDAcellular_component
GO:0005886Plasma membraneIDA IEAcellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0005911Cell-cell junctionIEA ISScellular_component
GO:0006508ProteolysisIDA IEAbiological_process
GO:0008233Peptidase activityIDAmolecular_function
GO:0008236Serine-type peptidase activityIDAmolecular_function
GO:0008360Regulation of cell shapeIMPbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010628Positive regulation of gene expressionIEA ISSbiological_process
GO:0010719Negative regulation of epithelial to mesenchymal transitionIDAbiological_process
GO:0010756Positive regulation of plasminogen activationIDAbiological_process
GO:0015269Calcium-activated potassium channel activityIEA ISSmolecular_function
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIDAcellular_component
GO:0030307Positive regulation of cell growthIMPbiological_process
GO:0031965Nuclear membraneIDAcellular_component
GO:0034769Basement membrane disassemblyIDAbiological_process
GO:0043025Neuronal cell bodyIEA ISScellular_component
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0043923Positive regulation by host of viral transcriptionIDAbiological_process
GO:0050680Negative regulation of epithelial cell proliferationIDAbiological_process
GO:0050910Detection of mechanical stimulus involved in sensory perception of soundIEA ISSbiological_process
GO:0060429Epithelium developmentIEAbiological_process
GO:0070008Serine-type exopeptidase activityIEAmolecular_function
GO:0071805Potassium ion transmembrane transportISSbiological_process
GO:0090103Cochlea morphogenesisIEA ISSbiological_process
GO:0097066Response to thyroid hormoneIEA ISSbiological_process
GO:0097195Pilomotor reflexIEA ISSbiological_process
GO:2000347Positive regulation of hepatocyte proliferationIDAbiological_process
GO:2000611Positive regulation of thyroid hormone generationIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.43329290680.83544874810.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0151039607
GSE13712_SHEARUp0.3857179818
GSE13712_STATICUp0.2800412455
GSE19018Up0.2398350906
GSE19899_A1Down-0.1119018296
GSE19899_A2Up0.1526832532
PubMed_21979375_A1Down-0.1173128122
PubMed_21979375_A2Down-0.0068145044
GSE35957Up0.2017283572
GSE36640Up0.0671687623
GSE54402Down-0.0162411502
GSE9593Down-0.1780800587
GSE43922Up0.0298146513
GSE24585Up0.0499371360
GSE37065Down-0.0825933631
GSE28863_A1Down-0.1775574520
GSE28863_A2Down-0.1190511492
GSE28863_A3Up0.3869323131
GSE28863_A4Up0.1569924431
GSE48662Down-0.0431059982

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Coagulation factor VIIa Recombinant HumanDB00036 BTD00006 | BIOD00006
BentiromideDB00522 APRD00818
Benzylsulfinic AcidDB03297 EXPT02622
CRA_1144DB03643 EXPT01013
6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-CarboxamidineDB03865 EXPT00023

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-197-3pMIMAT0000227MIRT004197MicroarrayFunctional MTI (Weak)16822819
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

12172426Some, such as hepsin, not only show increased expression in cancer, but can also provide prognostic information on prostate tumors based on their level of expression
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