HCSGD entry for HPN
1. General information
Official gene symbol | HPN |
---|---|
Entrez ID | 3249 |
Gene full name | hepsin |
Other gene symbols | TMPRSS1 |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network

This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0004252 | Serine-type endopeptidase activity | IDA IEA | molecular_function |
GO:0005044 | Scavenger receptor activity | IEA | molecular_function |
GO:0005515 | Protein binding | IPI | molecular_function |
GO:0005737 | Cytoplasm | IDA | cellular_component |
GO:0005789 | Endoplasmic reticulum membrane | IDA | cellular_component |
GO:0005886 | Plasma membrane | IDA IEA | cellular_component |
GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
GO:0005911 | Cell-cell junction | IEA ISS | cellular_component |
GO:0006508 | Proteolysis | IDA IEA | biological_process |
GO:0008233 | Peptidase activity | IDA | molecular_function |
GO:0008236 | Serine-type peptidase activity | IDA | molecular_function |
GO:0008360 | Regulation of cell shape | IMP | biological_process |
GO:0009986 | Cell surface | IDA | cellular_component |
GO:0010628 | Positive regulation of gene expression | IEA ISS | biological_process |
GO:0010719 | Negative regulation of epithelial to mesenchymal transition | IDA | biological_process |
GO:0010756 | Positive regulation of plasminogen activation | IDA | biological_process |
GO:0015269 | Calcium-activated potassium channel activity | IEA ISS | molecular_function |
GO:0016020 | Membrane | IEA | cellular_component |
GO:0016021 | Integral component of membrane | IDA | cellular_component |
GO:0030307 | Positive regulation of cell growth | IMP | biological_process |
GO:0031965 | Nuclear membrane | IDA | cellular_component |
GO:0034769 | Basement membrane disassembly | IDA | biological_process |
GO:0043025 | Neuronal cell body | IEA ISS | cellular_component |
GO:0043066 | Negative regulation of apoptotic process | IDA | biological_process |
GO:0043923 | Positive regulation by host of viral transcription | IDA | biological_process |
GO:0050680 | Negative regulation of epithelial cell proliferation | IDA | biological_process |
GO:0050910 | Detection of mechanical stimulus involved in sensory perception of sound | IEA ISS | biological_process |
GO:0060429 | Epithelium development | IEA | biological_process |
GO:0070008 | Serine-type exopeptidase activity | IEA | molecular_function |
GO:0071805 | Potassium ion transmembrane transport | ISS | biological_process |
GO:0090103 | Cochlea morphogenesis | IEA ISS | biological_process |
GO:0097066 | Response to thyroid hormone | IEA ISS | biological_process |
GO:0097195 | Pilomotor reflex | IEA ISS | biological_process |
GO:2000347 | Positive regulation of hepatocyte proliferation | IDA | biological_process |
GO:2000611 | Positive regulation of thyroid hormone generation | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.4332929068 | 0.8354487481 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Down | -0.0151039607 |
GSE13712_SHEAR | Up | 0.3857179818 |
GSE13712_STATIC | Up | 0.2800412455 |
GSE19018 | Up | 0.2398350906 |
GSE19899_A1 | Down | -0.1119018296 |
GSE19899_A2 | Up | 0.1526832532 |
PubMed_21979375_A1 | Down | -0.1173128122 |
PubMed_21979375_A2 | Down | -0.0068145044 |
GSE35957 | Up | 0.2017283572 |
GSE36640 | Up | 0.0671687623 |
GSE54402 | Down | -0.0162411502 |
GSE9593 | Down | -0.1780800587 |
GSE43922 | Up | 0.0298146513 |
GSE24585 | Up | 0.0499371360 |
GSE37065 | Down | -0.0825933631 |
GSE28863_A1 | Down | -0.1775574520 |
GSE28863_A2 | Down | -0.1190511492 |
GSE28863_A3 | Up | 0.3869323131 |
GSE28863_A4 | Up | 0.1569924431 |
GSE48662 | Down | -0.0431059982 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
---|---|---|
Coagulation factor VIIa Recombinant Human | DB00036 | BTD00006 | BIOD00006 |
Bentiromide | DB00522 | APRD00818 |
Benzylsulfinic Acid | DB03297 | EXPT02622 |
CRA_1144 | DB03643 | EXPT01013 |
6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine | DB03865 | EXPT00023 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
---|---|---|---|---|---|
hsa-miR-197-3p | MIMAT0000227 | MIRT004197 | Microarray | Functional MTI (Weak) | 16822819 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
---|---|
12172426 | Some, such as hepsin, not only show increased expression in cancer, but can also provide prognostic information on prostate tumors based on their level of expression |
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