HCSGD entry for HOXC8
1. General information
| Official gene symbol | HOXC8 |
|---|---|
| Entrez ID | 3224 |
| Gene full name | homeobox C8 |
| Other gene symbols | HOX3 HOX3A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0000976 | Transcription regulatory region sequence-specific DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0009952 | Anterior/posterior pattern specification | IEA | biological_process |
| GO:0030182 | Neuron differentiation | IEA | biological_process |
| GO:0048705 | Skeletal system morphogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8644022226 | 0.1797936857 | 0.9999902473 | 0.8209970165 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0626370526 |
| GSE13712_SHEAR | Down | -0.0581197414 |
| GSE13712_STATIC | Up | 0.0583051672 |
| GSE19018 | Down | -0.0457051675 |
| GSE19899_A1 | Up | 0.0318909455 |
| GSE19899_A2 | Up | 0.1452411724 |
| PubMed_21979375_A1 | Down | -0.2034448130 |
| PubMed_21979375_A2 | Down | -0.0853030851 |
| GSE35957 | Up | 0.1316679272 |
| GSE36640 | Down | -0.1050598576 |
| GSE54402 | Down | -0.0497751423 |
| GSE9593 | Down | -0.1327133628 |
| GSE43922 | Up | 0.0346079430 |
| GSE24585 | Up | 0.2187572715 |
| GSE37065 | Down | -0.3662188463 |
| GSE28863_A1 | Down | -0.5456659658 |
| GSE28863_A2 | Down | -0.2624673875 |
| GSE28863_A3 | Down | -0.2306541202 |
| GSE28863_A4 | Up | 0.1213735695 |
| GSE48662 | Up | 0.1615169316 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-196a-5p | MIMAT0000226 | MIRT002942 | Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay;Other | Functional MTI | 19063684 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT002942 | Luciferase reporter assay//qRT-PCR//Reporter assay;Western blot;qRT-PCR | Functional MTI | 21077158 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT002942 | Western blot | Functional MTI | 19418581 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT002942 | Immunohistochemistry//Luciferase reporter assay//qRT-PCR | Functional MTI | 20736365 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT002942 | Luciferase reporter assay | Functional MTI | 15105502 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT002942 | qRT-PCR//Western blot | Functional MTI | 22545021 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT002942 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT002942 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196b-5p | MIMAT0001080 | MIRT004638 | Immunohistochemistry//Luciferase reporter assay//qRT-PCR | Functional MTI | 20736365 |
| hsa-miR-196b-5p | MIMAT0001080 | MIRT004638 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020127 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-148a-3p | MIMAT0000243 | MIRT026011 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031090 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050144 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-196a-5p | MIMAT0000226 | 1 | hsa-miR-196a | 15105502 | |||
| hsa-miR-196a-5p | MIMAT0000226 | 1 | hsa-miR-196a | {Western blot} | {overexpression by miRNA mimics tranfection} | 19063684 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
