HCSGD entry for HOXB8
1. General information
| Official gene symbol | HOXB8 |
|---|---|
| Entrez ID | 3218 |
| Gene full name | homeobox B8 |
| Other gene symbols | HOX2 HOX2D Hox-2.4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000976 | Transcription regulatory region sequence-specific DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0007625 | Grooming behavior | IEA | biological_process |
| GO:0008344 | Adult locomotory behavior | IEA | biological_process |
| GO:0009952 | Anterior/posterior pattern specification | IEA | biological_process |
| GO:0019233 | Sensory perception of pain | IEA | biological_process |
| GO:0021516 | Dorsal spinal cord development | IEA | biological_process |
| GO:0045638 | Negative regulation of myeloid cell differentiation | IEA ISS | biological_process |
| GO:0048704 | Embryonic skeletal system morphogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0369259109 | 0.8651706280 | 0.4363235189 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0097243876 |
| GSE13712_SHEAR | Up | 1.0058180468 |
| GSE13712_STATIC | Up | 1.0924798681 |
| GSE19018 | Up | 0.1132223219 |
| GSE19899_A1 | Down | -0.0672626744 |
| GSE19899_A2 | Up | 0.3990699821 |
| PubMed_21979375_A1 | Down | -0.8898666803 |
| PubMed_21979375_A2 | Down | -0.4102889622 |
| GSE35957 | Up | 0.0025289752 |
| GSE36640 | Up | 1.2732079480 |
| GSE54402 | Down | -0.0944887315 |
| GSE9593 | Up | 0.0303432887 |
| GSE43922 | Up | 0.0459640693 |
| GSE24585 | Up | 0.6896672198 |
| GSE37065 | Up | 0.0759957436 |
| GSE28863_A1 | Down | -0.1662447289 |
| GSE28863_A2 | Up | 0.1820788083 |
| GSE28863_A3 | Up | 0.2805544264 |
| GSE28863_A4 | Up | 0.1467720579 |
| GSE48662 | Up | 0.2128545685 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-196b-5p | MIMAT0001080 | MIRT001042 | Luciferase reporter assay | Functional MTI | 18493311 |
| hsa-miR-196b-5p | MIMAT0001080 | MIRT001042 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT002266 | Western blot | Functional MTI | 19418581 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT002266 | Luciferase reporter assay | Functional MTI | 18493311 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT002266 | Luciferase reporter assay | Functional MTI | 15105502 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT002266 | Luciferase reporter assay//Northern blot//Western blot | Functional MTI | 17150553 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT002266 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025552 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-320a | MIMAT0000510 | MIRT044624 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-196a-5p | MIMAT0000226 | 1 | hsa-miR-196a | 15105502 | |||
| hsa-miR-196a-5p | MIMAT0000226 | 1 | hsa-miR-196a | {Western blot}{Western blot} | {overexpression}{mutation} | 17150553 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
