HCSGD entry for HNRNPK
1. General information
| Official gene symbol | HNRNPK |
|---|---|
| Entrez ID | 3190 |
| Gene full name | heterogeneous nuclear ribonucleoprotein K |
| Other gene symbols | CSBP HNRPK TUNP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000398 | MRNA splicing, via spliceosome | IC TAS | biological_process |
| GO:0000790 | Nuclear chromatin | IDA | cellular_component |
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IMP | molecular_function |
| GO:0001077 | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | IMP | molecular_function |
| GO:0002102 | Podosome | IEA | cellular_component |
| GO:0003697 | Single-stranded DNA binding | TAS | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | IMP | biological_process |
| GO:0006396 | RNA processing | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010988 | Regulation of low-density lipoprotein particle clearance | IMP | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0030054 | Cell junction | IEA | cellular_component |
| GO:0042995 | Cell projection | IEA | cellular_component |
| GO:0045716 | Positive regulation of low-density lipoprotein particle receptor biosynthetic process | IMP | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IMP | biological_process |
| GO:0048260 | Positive regulation of receptor-mediated endocytosis | IMP | biological_process |
| GO:0071013 | Catalytic step 2 spliceosome | IDA | cellular_component |
| GO:0072369 | Regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9851320770 | 0.1368277535 | 0.9999902473 | 0.7127336830 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0204889546 |
| GSE13712_SHEAR | Down | -0.1321018461 |
| GSE13712_STATIC | Down | -0.1107436743 |
| GSE19018 | Down | -0.1664767207 |
| GSE19899_A1 | Down | -0.3041691548 |
| GSE19899_A2 | Down | -0.2847839702 |
| PubMed_21979375_A1 | Down | -0.3476369189 |
| PubMed_21979375_A2 | Down | -0.3351835253 |
| GSE35957 | Down | -0.1647425272 |
| GSE36640 | Down | -0.2368154477 |
| GSE54402 | Up | 0.0543174492 |
| GSE9593 | Down | -0.1946227063 |
| GSE43922 | Down | -0.0202152994 |
| GSE24585 | Up | 0.0395134147 |
| GSE37065 | Down | -0.0001112309 |
| GSE28863_A1 | Up | 0.0066832503 |
| GSE28863_A2 | Up | 0.0800002148 |
| GSE28863_A3 | Up | 0.1095713646 |
| GSE28863_A4 | Down | -0.0978893232 |
| GSE48662 | Down | -0.2854968124 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-450a-5p | MIMAT0001545 | MIRT004345 | Western blot//Microarray | Functional MTI | 18230805 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT005325 | Luciferase reporter assay//qRT-PCR | Functional MTI | 18829576 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037186 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-3p | MIMAT0004672 | MIRT038583 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040216 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-503-5p | MIMAT0002874 | MIRT041102 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042152 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-328-3p | MIMAT0000752 | MIRT043787 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT045940 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046352 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046389 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047832 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052770 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25512341 | Instead, lincRNA-p21 associates with the H3K9 methyltransferase SETDB1 and the maintenance DNA methyltransferase DNMT1, which is facilitated by the RNA-binding protein HNRNPK |
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