HCSGD entry for HNRNPD

1. General information

Official gene symbolHNRNPD
Entrez ID3184
Gene full nameheterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
Other gene symbolsAUF1 AUF1A HNRPD P37 hnRNPD0
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000166Nucleotide bindingIEAmolecular_function
GO:0000398MRNA splicing, via spliceosomeTASbiological_process
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003723RNA bindingIDA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA NAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedNASbiological_process
GO:0006396RNA processingTASbiological_process
GO:0006401RNA catabolic processTASbiological_process
GO:0008380RNA splicingTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0019013Viral nucleocapsidIEAcellular_component
GO:0030529Ribonucleoprotein complexIDA IEAcellular_component
GO:0042162Telomeric DNA bindingIDAmolecular_function
GO:0043488Regulation of mRNA stabilityIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedNASbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.98923263930.00662310320.99999024730.1641603561

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2699677784
GSE13712_SHEARDown-0.2348848381
GSE13712_STATICDown-0.0891598418
GSE19018Down-0.1913902683
GSE19899_A1Down-0.5326545641
GSE19899_A2Down-0.7468349425
PubMed_21979375_A1Down-0.7694049607
PubMed_21979375_A2Down-1.2367526415
GSE35957Down-0.4461649262
GSE36640Down-0.9629698209
GSE54402Down-0.1445836370
GSE9593Down-0.4755703309
GSE43922Down-0.7325434603
GSE24585Down-0.2913064640
GSE37065Down-0.0670365410
GSE28863_A1Up0.4617500522
GSE28863_A2Up0.3556240899
GSE28863_A3Down-0.0502671074
GSE28863_A4Up0.0326099392
GSE48662Down-0.7189300235

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-197-3pMIMAT0000227MIRT004177MicroarrayFunctional MTI (Weak)16822819
hsa-miR-1MIMAT0000416MIRT024012ProteomicsFunctional MTI (Weak)18668040
hsa-miR-221-3pMIMAT0000278MIRT024179SequencingFunctional MTI (Weak)20371350
hsa-miR-1229-3pMIMAT0005584MIRT036291CLASHFunctional MTI (Weak)23622248
hsa-miR-18a-3pMIMAT0002891MIRT040890CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046797CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26990999Our results indicate that metformin upregulates DICER1 through a post-transcriptional mechanism involving the RNA-binding protein AUF1
26990999Treatment with metformin altered the subcellular localization of AUF1, disrupting its interaction with DICER1 mRNA and rendering DICER1 mRNA stable, allowing DICER1 to accumulate
25366541PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity
25366541Photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) analysis reveals that AUF1 primarily recognizes U-/GU-rich sequences in mRNAs and noncoding RNAs and influences target transcript fate in three main directions
25366541First, AUF1 lowers the steady-state levels of numerous target RNAs, including long noncoding RNA NEAT1, in turn affecting the organization of nuclear paraspeckles
25366541Second, AUF1 does not change the abundance of many target RNAs, but ribosome profiling reveals that AUF1 promotes the translation of numerous mRNAs in this group
25366541Third, AUF1 unexpectedly enhances the steady-state levels of several target mRNAs encoding DNA-maintenance proteins
25366541Through its actions on target RNAs, AUF1 preserves genomic integrity, in agreement with the AUF1-elicited prevention of premature cellular senescence
22633954Cessation of the inflammatory cytokine response is mediated in part through cytokine mRNA degradation facilitated by RNA-binding proteins, including AUF1
22633954AUF1-deficient mice undergo striking telomere erosion, markedly increased DNA damage responses at telomere ends, pronounced cellular senescence, and rapid premature aging that increases with successive generations, which can be rescued in AUF1 knockout mice and their cultured cells by resupplying AUF1 expression
22633954AUF1 binds and strongly activates the transcription promoter for telomerase catalytic subunit Tert
22633954Thus, a single gene, AUF1, links maintenance of telomere length and normal aging to attenuation of inflammatory cytokine expression and inhibition of cellular senescence
20069554The induction of p16 by H2O2 was accompanied with declined cytoplasmic AUF1 level
20069554Accordingly, exposure of cells to H2O2 remarkably reduced the binding of AUF1 to p16 3'UTR and increased the half-life of an EGFP-p16-3'UTR chimeric transcript
20069554Furthermore, in cells co-transfected with vectors expressing AUF1s, treatment with H2O2 failed to significantly reduce the expression of AUF1 and subsequently elevate the levels of p16
20069554Our results indicate that AUF1 is critical for H2O2-induced p16 expression and cellular senescence
Entries Per Page
Displaying Page of