HCSGD entry for HNRNPA1
1. General information
| Official gene symbol | HNRNPA1 |
|---|---|
| Entrez ID | 3178 |
| Gene full name | heterogeneous nuclear ribonucleoprotein A1 |
| Other gene symbols | HNRPA1 HNRPA1L3 hnRNP A1 hnRNP-A1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000398 | MRNA splicing, via spliceosome | IC TAS | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003697 | Single-stranded DNA binding | IDA | molecular_function |
| GO:0003723 | RNA binding | TAS | molecular_function |
| GO:0003727 | Single-stranded RNA binding | IC | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | IDA TAS | cellular_component |
| GO:0005681 | Spliceosomal complex | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006397 | MRNA processing | TAS | biological_process |
| GO:0006405 | RNA export from nucleus | IC | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0030529 | Ribonucleoprotein complex | IDA | cellular_component |
| GO:0045111 | Intermediate filament cytoskeleton | IDA | cellular_component |
| GO:0051028 | MRNA transport | IEA | biological_process |
| GO:0051168 | Nuclear export | IDA | biological_process |
| GO:0051170 | Nuclear import | IDA | biological_process |
| GO:0071013 | Catalytic step 2 spliceosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9921642453 | 0.0040052582 | 0.9999902473 | 0.1284073082 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3566120396 |
| GSE13712_SHEAR | Down | -0.0659444061 |
| GSE13712_STATIC | Down | -0.5560271880 |
| GSE19018 | Down | -0.8116926438 |
| GSE19899_A1 | Down | -0.4864430378 |
| GSE19899_A2 | Down | -0.3779081494 |
| PubMed_21979375_A1 | Down | -0.4616527386 |
| PubMed_21979375_A2 | Down | -0.4146733174 |
| GSE35957 | Down | -0.9041284875 |
| GSE36640 | Down | -0.3155995445 |
| GSE54402 | Down | -0.3222021043 |
| GSE9593 | Down | -0.2220092391 |
| GSE43922 | Up | 0.0244026174 |
| GSE24585 | Down | -0.2061744579 |
| GSE37065 | Down | -0.1650171067 |
| GSE28863_A1 | Up | 0.0756489383 |
| GSE28863_A2 | Down | -0.4796518153 |
| GSE28863_A3 | Down | -0.3310464326 |
| GSE28863_A4 | Down | -0.0400463848 |
| GSE48662 | Down | -0.5544722151 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT024037 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028678 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031226 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036122 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036356 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-22-5p | MIMAT0004495 | MIRT038961 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039996 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042186 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-339-5p | MIMAT0000764 | MIRT042762 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043217 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-194-5p | MIMAT0000460 | MIRT044875 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045060 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048099 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT048737 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050353 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052722 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27363602 | Two splicing regulators, HNRNPA1 and HNRNPA2B1, were also associated with parental longevity in humans, in the InCHIANTI aging study |
| 22227431 | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is an RNA-binding protein that modulates splice site usage, polyadenylation, and cleavage efficiency |
| 19430204 | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a RNA binding protein that plays important role in the biogenesis of mRNA, such as alternative splicing and mRNA stability |
| 9620782 | Here, it is shown that the heterogeneous nuclear ribonucleoprotein A1 participates in telomere biogenesis |
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