HCSGD entry for HNMT
1. General information
| Official gene symbol | HNMT |
|---|---|
| Entrez ID | 3176 |
| Gene full name | histamine N-methyltransferase |
| Other gene symbols | HMT HNMT-S1 HNMT-S2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002347 | Response to tumor cell | IEA | biological_process |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006972 | Hyperosmotic response | IEA | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0007585 | Respiratory gaseous exchange | TAS | biological_process |
| GO:0014075 | Response to amine | IEA | biological_process |
| GO:0042220 | Response to cocaine | IEA | biological_process |
| GO:0043005 | Neuron projection | IEA | cellular_component |
| GO:0046539 | Histamine N-methyltransferase activity | IEA | molecular_function |
| GO:0051384 | Response to glucocorticoid | IEA | biological_process |
| GO:0070555 | Response to interleukin-1 | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9946288857 | 0.0046311804 | 0.9999902473 | 0.1377370621 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0909658748 |
| GSE13712_SHEAR | Down | -0.3244039549 |
| GSE13712_STATIC | Down | -0.5260222704 |
| GSE19018 | Down | -0.7999714864 |
| GSE19899_A1 | Down | -0.1839206074 |
| GSE19899_A2 | Down | -0.5785996242 |
| PubMed_21979375_A1 | Up | 0.3190935571 |
| PubMed_21979375_A2 | Down | -0.5085531031 |
| GSE35957 | Down | -0.6702943228 |
| GSE36640 | Down | -0.0463158319 |
| GSE54402 | Down | -0.8196673240 |
| GSE9593 | Down | -0.8766214759 |
| GSE43922 | Down | -0.2906381212 |
| GSE24585 | Up | 0.1885180451 |
| GSE37065 | Down | -0.5856476026 |
| GSE28863_A1 | Down | -0.0666660700 |
| GSE28863_A2 | Up | 0.0146942578 |
| GSE28863_A3 | Down | -0.2118988260 |
| GSE28863_A4 | Down | -0.2367562062 |
| GSE48662 | Down | -0.2273333403 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Compound | Target | Confidence score | Uniprot |
|---|---|---|---|
| CHEMBL607884 | CHEMBL2190 | 8 | P50135 |
| CHEMBL342283 | CHEMBL2190 | 8 | P50135 |
| CHEMBL342283 | CHEMBL2190 | 8 | P50135 |
| CHEMBL607884 | CHEMBL2190 | 8 | P50135 |
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Amodiaquine | DB00613 | APRD00796 |
| S-Adenosyl-L-Homocysteine | DB01752 | EXPT02842 |
| METOPRINE, METHODICHLOROPHEN | DB04655 | - |
| 4-(DIMETHYLAMINO)BUTYL IMIDOTHIOCARBAMATE | DB07106 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25672483 | Additionally, ING2 recruits histone methyltransferase (HMT) activity for gene repression, which is independent of the HDAC class I or II pathway |
| 24528089 | The alterations in the mRNA and protein levels of histone acetyltransferases (HATs), histone methyltransferase (HMT), and histone deacetylases (HDACs) indicate that differential expression exists between replicative and premature senescent cells |
| 24528089 | In summary, the global hypoacetylation of histone H3 and H4 and the hypertrimethylation of histone H4 lysine 20 account for epigenetic characteristics in senescence, controlled by HATs, HMT, and HDACs differentially between replicative and premature senescence |
| 18513492 | In line with that we show that p33ING2 is associated with histone methyltransferase (HMT) activity in vitro and in vivo, methylating specifically histone H3 |
| 18513492 | Interestingly, the specificity is distinct from the MeCP2-recruited HMT |
| 18513492 | Instead, the ING2-associated HMT shows an increased methylation activity if lysine 9 is methylated |
| 18513492 | In contrast, mutation or methylation of lysine 4, a methylation preferentially detected at active genes, led to a reduction of the ING2-associated HMT |
| 18513492 | Notably, also p33ING1 recruits HMT activity suggesting a more general biochemical interaction between members of p33ING family and HMT activity |
| 18513492 | Deletion analyses revealed that the ING2 C-terminus recruits HMT activity, which correlates with silencing function |
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