HCSGD entry for AOX1
1. General information
| Official gene symbol | AOX1 |
|---|---|
| Entrez ID | 316 |
| Gene full name | aldehyde oxidase 1 |
| Other gene symbols | AO AOH1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004031 | Aldehyde oxidase activity | IEA TAS | molecular_function |
| GO:0004854 | Xanthine dehydrogenase activity | TAS | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006766 | Vitamin metabolic process | TAS | biological_process |
| GO:0006767 | Water-soluble vitamin metabolic process | TAS | biological_process |
| GO:0006954 | Inflammatory response | TAS | biological_process |
| GO:0008762 | UDP-N-acetylmuramate dehydrogenase activity | IEA | molecular_function |
| GO:0009055 | Electron carrier activity | IEA | molecular_function |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0042816 | Vitamin B6 metabolic process | TAS | biological_process |
| GO:0043546 | Molybdopterin cofactor binding | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050660 | Flavin adenine dinucleotide binding | IEA | molecular_function |
| GO:0051287 | NAD binding | IEA | molecular_function |
| GO:0051537 | 2 iron, 2 sulfur cluster binding | IEA | molecular_function |
| GO:0072593 | Reactive oxygen species metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0009204589 | 0.6273856350 | 0.0829554422 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.7689766875 |
| GSE13712_SHEAR | Up | 0.0794755344 |
| GSE13712_STATIC | Up | 0.1066619894 |
| GSE19018 | Up | 1.3267934034 |
| GSE19899_A1 | Up | 0.1922435520 |
| GSE19899_A2 | Up | 1.0763638915 |
| PubMed_21979375_A1 | Up | 1.1989117926 |
| PubMed_21979375_A2 | Up | 0.8070451358 |
| GSE35957 | Up | 2.2250377053 |
| GSE36640 | Up | 1.5680570259 |
| GSE54402 | Down | -1.0946858150 |
| GSE9593 | Up | 0.5361861800 |
| GSE43922 | Down | -0.2043153532 |
| GSE24585 | Up | 0.1700621496 |
| GSE37065 | Down | -0.4655935818 |
| GSE28863_A1 | Up | 0.7906391138 |
| GSE28863_A2 | Up | 1.6298408347 |
| GSE28863_A3 | Down | -0.5692630155 |
| GSE28863_A4 | Down | -0.3207048714 |
| GSE48662 | Down | -0.1082894131 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Eniluracil | DB03516 | EXPT03299 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029520 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23274001 | 77 (nmol/min/mg protein) and upregulated the gene expression levels of copper transport protein ATOX1, glutathione synthetase (GSS) and thioredoxin reductase 1 (TXNRD1) while down-regulated aldehyde oxidase 1 (AOX1) |
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