HCSGD entry for HMGCS1
1. General information
| Official gene symbol | HMGCS1 |
|---|---|
| Entrez ID | 3157 |
| Gene full name | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) |
| Other gene symbols | HMGCS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001101 | Response to acid | IEA | biological_process |
| GO:0001889 | Liver development | IEA | biological_process |
| GO:0004421 | Hydroxymethylglutaryl-CoA synthase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006629 | Lipid metabolic process | NAS | biological_process |
| GO:0006695 | Cholesterol biosynthetic process | TAS | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0008144 | Drug binding | IEA | molecular_function |
| GO:0008299 | Isoprenoid biosynthetic process | IEA | biological_process |
| GO:0008584 | Male gonad development | IEA | biological_process |
| GO:0009645 | Response to low light intensity stimulus | IEA | biological_process |
| GO:0014074 | Response to purine-containing compound | IEA | biological_process |
| GO:0016853 | Isomerase activity | IEA | molecular_function |
| GO:0033197 | Response to vitamin E | IEA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
| GO:0043177 | Organic acid binding | IEA | molecular_function |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046690 | Response to tellurium ion | IEA | biological_process |
| GO:0055094 | Response to lipoprotein particle | IEA | biological_process |
| GO:0071372 | Cellular response to follicle-stimulating hormone stimulus | IEA | biological_process |
| GO:0071397 | Cellular response to cholesterol | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0264985905 | 0.0512598723 | 0.3794719260 | 0.4260069444 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6659554040 |
| GSE13712_SHEAR | Down | -0.2166019669 |
| GSE13712_STATIC | Down | -0.6080785361 |
| GSE19018 | Down | -0.8091449948 |
| GSE19899_A1 | Up | 0.5903475897 |
| GSE19899_A2 | Up | 1.4627489836 |
| PubMed_21979375_A1 | Down | -0.9974656647 |
| PubMed_21979375_A2 | Up | 0.2022636605 |
| GSE35957 | Up | 0.2978033245 |
| GSE36640 | Up | 1.7342991866 |
| GSE54402 | Down | -0.0942233182 |
| GSE9593 | Up | 0.1784714985 |
| GSE43922 | Up | 0.1669060370 |
| GSE24585 | Down | -0.6307902067 |
| GSE37065 | Up | 0.1592996656 |
| GSE28863_A1 | Up | 0.3740095456 |
| GSE28863_A2 | Up | 0.5680517416 |
| GSE28863_A3 | Down | -0.9559481601 |
| GSE28863_A4 | Up | 0.1211440805 |
| GSE48662 | Down | -1.0827966837 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| (3R,5S,7R,12S,13R)-13-FORMYL-12,14-DIHYDROXY-3,5,7-TRIMETHYLTETRADECANOIC ACID | DB07740 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017138 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021092 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026269 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT027892 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031085 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT031353 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1301-3p | MIMAT0005797 | MIRT035970 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-3p | MIMAT0003887 | MIRT039071 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049260 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052336 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-3176 | MIMAT0015053 | MIRT052793 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
