HCSGD entry for HMGCL

1. General information

Official gene symbolHMGCL
Entrez ID3155
Gene full name3-hydroxymethyl-3-methylglutaryl-CoA lyase
Other gene symbolsHL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000062Fatty-acyl-CoA bindingIEAmolecular_function
GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0001889Liver developmentIEAbiological_process
GO:0004419Hydroxymethylglutaryl-CoA lyase activityIDA IEA TASmolecular_function
GO:0005102Receptor bindingIPImolecular_function
GO:0005739MitochondrionIDAcellular_component
GO:0005743Mitochondrial inner membraneIEAcellular_component
GO:0005759Mitochondrial matrixNAS TAScellular_component
GO:0005777PeroxisomeIDAcellular_component
GO:0006552Leucine catabolic processNASbiological_process
GO:0006637Acyl-CoA metabolic processIEAbiological_process
GO:0007005Mitochondrion organizationIEAbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0009790Embryo developmentIEAbiological_process
GO:0030145Manganese ion bindingIDAmolecular_function
GO:0031406Carboxylic acid bindingIEAmolecular_function
GO:0042594Response to starvationIEAbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046872Metal ion bindingIDAmolecular_function
GO:0046950Cellular ketone body metabolic processTASbiological_process
GO:0046951Ketone body biosynthetic processIDA IEA TASbiological_process
GO:0051262Protein tetramerizationIDAbiological_process
GO:0070542Response to fatty acidIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07068629230.87984108510.56810195421.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0898910886
GSE13712_SHEARDown-0.1084334757
GSE13712_STATICUp0.0019025568
GSE19018Up0.8814050255
GSE19899_A1Down-0.0207240902
GSE19899_A2Up0.6026153608
PubMed_21979375_A1Down-0.0528586290
PubMed_21979375_A2Up0.3565737442
GSE35957Down-0.2372726244
GSE36640Up0.6262127609
GSE54402Down-0.0900465204
GSE9593Up0.1587670712
GSE43922Up0.0459739950
GSE24585Up0.9001879097
GSE37065Up0.0655563929
GSE28863_A1Down-0.1194680707
GSE28863_A2Down-0.0464315123
GSE28863_A3Down-0.3762407088
GSE28863_A4Down-0.1222185961
GSE48662Up0.4193758373

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

3-hydroxyglutaric acidDB04594 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-106b-5pMIMAT0000680MIRT044352CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.