HCSGD entry for HLX
1. General information
| Official gene symbol | HLX |
|---|---|
| Entrez ID | 3142 |
| Gene full name | H2.0-like homeobox |
| Other gene symbols | HB24 HLX1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000976 | Transcription regulatory region sequence-specific DNA binding | IEA | molecular_function |
| GO:0001889 | Liver development | IEA | biological_process |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0007519 | Skeletal muscle tissue development | IEA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IDA | molecular_function |
| GO:0045627 | Positive regulation of T-helper 1 cell differentiation | IEA | biological_process |
| GO:0045629 | Negative regulation of T-helper 2 cell differentiation | IEA | biological_process |
| GO:0046622 | Positive regulation of organ growth | IEA | biological_process |
| GO:0048484 | Enteric nervous system development | IEA | biological_process |
| GO:0048557 | Embryonic digestive tract morphogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3489536492 | 0.5522860682 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3338650548 |
| GSE13712_SHEAR | Down | -1.3736286302 |
| GSE13712_STATIC | Down | -0.5250404847 |
| GSE19018 | Up | 0.1971345778 |
| GSE19899_A1 | Down | -0.1773203709 |
| GSE19899_A2 | Down | -0.0972726952 |
| PubMed_21979375_A1 | Up | 0.1973742839 |
| PubMed_21979375_A2 | Up | 0.0890081430 |
| GSE35957 | Down | -0.0002291161 |
| GSE36640 | Down | -0.1472009112 |
| GSE54402 | Up | 0.0649228933 |
| GSE9593 | Up | 0.2451684082 |
| GSE43922 | Up | 0.0549807864 |
| GSE24585 | Down | -0.1145285690 |
| GSE37065 | Down | -0.0141204488 |
| GSE28863_A1 | Down | -0.0252521706 |
| GSE28863_A2 | Up | 0.2767037592 |
| GSE28863_A3 | Up | 0.1967466830 |
| GSE28863_A4 | Up | 0.0148592478 |
| GSE48662 | Up | 0.3405832694 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1260b | MIMAT0015041 | MIRT052679 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24067365 | Recently we discovered the ability of the homeobox proteins HLX1 (H2 |
| 24067365 | We showed that HLX1 and HOXA9 recruit PRCs to repress INK4a, which constitutes a key mechanism explaining their effects on senescence |
| 24067365 | Here we provide evidence for the regulation of additional senescence-associated PRC target genes by HLX1 and HOXA9 |
| 24067365 | As both HLX1 and HOXA9 are oncogenes implicated in leukemogenesis, we discuss the implications that the collaboration between Homeobox proteins and PRCs has for senescence and cancer |
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