HCSGD entry for HLA-G

1. General information

Official gene symbolHLA-G
Entrez ID3135
Gene full namemajor histocompatibility complex, class I, G
Other gene symbolsMHC-G
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0001916Positive regulation of T cell mediated cytotoxicityIEAbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class IIEA TASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0002480Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentTASbiological_process
GO:0002666Positive regulation of T cell tolerance inductionIMPbiological_process
GO:0002767Immune response-inhibiting cell surface receptor signaling pathwayIDAbiological_process
GO:0005102Receptor bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0006955Immune responseIEAbiological_process
GO:0006968Cellular defense responseTASbiological_process
GO:0012507ER to Golgi transport vesicle membraneTAScellular_component
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0030670Phagocytic vesicle membraneTAScellular_component
GO:0031901Early endosome membraneTAScellular_component
GO:0032735Positive regulation of interleukin-12 productionIDAbiological_process
GO:0042130Negative regulation of T cell proliferationIDAbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042605Peptide antigen bindingIBA IEAmolecular_function
GO:0042612MHC class I protein complexIEAcellular_component
GO:0042803Protein homodimerization activityNASmolecular_function
GO:0045591Positive regulation of regulatory T cell differentiationIMPbiological_process
GO:0050776Regulation of immune responseTASbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
GO:0071556Integral component of lumenal side of endoplasmic reticulum membraneTAScellular_component
GO:2001199Negative regulation of dendritic cell differentiationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.39322204320.62620084720.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0836637807
GSE13712_SHEARUp0.4004728301
GSE13712_STATICUp0.3506203406
GSE19018Up0.5600174991
GSE19899_A1Down-0.2691475125
GSE19899_A2Up0.2730601069
PubMed_21979375_A1Down-0.3317972423
PubMed_21979375_A2Down-0.6391031549
GSE35957Down-0.2151431572
GSE36640Up0.5938996081
GSE54402Down-0.1268572477
GSE9593Up0.0499010910
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.1550202171

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-152-3pMIMAT0000438MIRT000293Luciferase reporter assayFunctional MTI17847008
hsa-miR-148b-3pMIMAT0000759MIRT000295Luciferase reporter assayFunctional MTI17847008
hsa-miR-148a-3pMIMAT0000243MIRT000297Luciferase reporter assayFunctional MTI17847008
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24337384The endosomal innate receptor CD158d (killer cell Ig-like receptor 2DL4) induces cellular senescence in human NK cells in response to soluble ligand (HLA-G or agonist Ab)
23184984NK cells are abundant at the maternal-fetal interface, where soluble HLA-G is produced by fetal trophoblast cells during early pregnancy
23184984Soluble HLA-G induces a proinflammatory response in primary, resting NK cells on endocytosis into early endosomes where its receptor, CD158d, resides
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