HCSGD entry for HLF
1. General information
| Official gene symbol | HLF |
|---|---|
| Entrez ID | 3131 |
| Gene full name | hepatic leukemia factor |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003690 | Double-stranded DNA binding | TAS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0035914 | Skeletal muscle cell differentiation | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0048511 | Rhythmic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6361808328 | 0.8061337411 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0556855138 |
| GSE13712_SHEAR | Up | 0.0598461076 |
| GSE13712_STATIC | Down | -0.0115177924 |
| GSE19018 | Up | 0.0665256413 |
| GSE19899_A1 | Up | 0.1815777386 |
| GSE19899_A2 | Up | 0.0998815686 |
| PubMed_21979375_A1 | Up | 0.3314109312 |
| PubMed_21979375_A2 | Up | 0.0062886071 |
| GSE35957 | Down | -0.0676323773 |
| GSE36640 | Down | -0.0439264796 |
| GSE54402 | Up | 0.0148639574 |
| GSE9593 | Up | 0.0570113466 |
| GSE43922 | Up | 0.0892392429 |
| GSE24585 | Down | -0.2683629341 |
| GSE37065 | Down | -0.1522343218 |
| GSE28863_A1 | Down | -0.0442592135 |
| GSE28863_A2 | Down | -0.0017589632 |
| GSE28863_A3 | Up | 0.2469318394 |
| GSE28863_A4 | Up | 0.0633790431 |
| GSE48662 | Down | -0.0708536203 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23339189 | In addition, human HCC cell lines (Hep3B, HepG2, HuH7, HLE, HLF, HepKK1, skHep1) were screened for the expression of the sirtuin family members and only SIRT1 was consistently overexpressed compared with normal hepatocytes |
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