HCSGD entry for HLA-C

1. General information

Official gene symbolHLA-C
Entrez ID3107
Gene full namemajor histocompatibility complex, class I, C
Other gene symbolsD6S204 HLA-JY3 HLC-C PSORS1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0001916Positive regulation of T cell mediated cytotoxicityIEAbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class IIEA TASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0002480Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentTASbiological_process
GO:0005102Receptor bindingIBAmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0006955Immune responseIEA NASbiological_process
GO:0012507ER to Golgi transport vesicle membraneTAScellular_component
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016032Viral processIEAbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0019882Antigen processing and presentationIEAbiological_process
GO:0030670Phagocytic vesicle membraneTAScellular_component
GO:0031901Early endosome membraneTAScellular_component
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042605Peptide antigen bindingIBA IEAmolecular_function
GO:0042612MHC class I protein complexIEAcellular_component
GO:0045087Innate immune responseTASbiological_process
GO:0050776Regulation of immune responseTASbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
GO:0071556Integral component of lumenal side of endoplasmic reticulum membraneTAScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.12363291290.74889461650.71851223231.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0378683903
GSE13712_SHEARUp0.5119692254
GSE13712_STATICUp0.4946317218
GSE19018Up1.1254357377
GSE19899_A1Down-0.1553755526
GSE19899_A2Up0.1315978900
PubMed_21979375_A1Down-0.2327738277
PubMed_21979375_A2Down-0.4924525792
GSE35957Down-0.2698624756
GSE36640Up0.9962479526
GSE54402Down-0.0242862598
GSE9593Down-0.0806796422
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.1685689214

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-484MIMAT0002174MIRT041720CLASHFunctional MTI (Weak)23622248
hsa-miR-423-3pMIMAT0001340MIRT042611CLASHFunctional MTI (Weak)23622248
hsa-let-7e-5pMIMAT0000066MIRT051644CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.