HCSGD entry for HK1
1. General information
| Official gene symbol | HK1 |
|---|---|
| Entrez ID | 3098 |
| Gene full name | hexokinase 1 |
| Other gene symbols | HK1-ta HK1-tb HK1-tc HKI HXK1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001678 | Cellular glucose homeostasis | IBA | biological_process |
| GO:0004340 | Glucokinase activity | IBA | molecular_function |
| GO:0004396 | Hexokinase activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA IEA | cellular_component |
| GO:0005741 | Mitochondrial outer membrane | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | IEA TAS | biological_process |
| GO:0006096 | Glycolysis | IBA IEA | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0008645 | Hexose transport | TAS | biological_process |
| GO:0008865 | Fructokinase activity | IBA | molecular_function |
| GO:0015758 | Glucose transport | TAS | biological_process |
| GO:0016773 | Phosphotransferase activity, alcohol group as acceptor | IEA | molecular_function |
| GO:0019158 | Mannokinase activity | IBA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045121 | Membrane raft | IEA | cellular_component |
| GO:0046835 | Carbohydrate phosphorylation | IBA TAS | biological_process |
| GO:0051156 | Glucose 6-phosphate metabolic process | IBA | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0048338931 | 0.9837900270 | 0.1830689209 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1304206635 |
| GSE13712_SHEAR | Up | 0.4269276228 |
| GSE13712_STATIC | Up | 0.1625504545 |
| GSE19018 | Up | 0.5729264112 |
| GSE19899_A1 | Up | 0.0297695941 |
| GSE19899_A2 | Up | 0.8505830670 |
| PubMed_21979375_A1 | Up | 1.5394285998 |
| PubMed_21979375_A2 | Up | 1.3997264991 |
| GSE35957 | Down | -0.0769177920 |
| GSE36640 | Down | -0.1157426915 |
| GSE54402 | Up | 0.9037428528 |
| GSE9593 | Up | 0.0715982787 |
| GSE43922 | Up | 0.3054583848 |
| GSE24585 | Down | -0.4675318009 |
| GSE37065 | Down | -0.0471421814 |
| GSE28863_A1 | Up | 0.4093988843 |
| GSE28863_A2 | Up | 0.7703463389 |
| GSE28863_A3 | Up | 0.5333472958 |
| GSE28863_A4 | Up | 0.1731566239 |
| GSE48662 | Down | -0.0548268490 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| alpha-D-glucose 6-phosphate | DB02007 | EXPT01537 |
| Beta-D-Glucose | DB02379 | EXPT00685 | EXPT00455 | EXPT01603 |
| Phosphoaminophosphonic Acid-Adenylate Ester | DB04395 | EXPT00524 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028427 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036117 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039926 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99b-5p | MIMAT0000689 | MIRT044199 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046245 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT047433 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047612 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048894 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052337 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 41984 | In the first period of the red cell life span the predominant form is similar to hexokinase II, while in the mature erythrocyte the predominant glucose phosphorylating activity resembles hexokinase I |
| 468260 | Increased HK1 activity levels in the red cells of a patient with a de novo trisomy 10p: t(Y;10)(p11;p12) |
| 468260 | The increased levels of HK1 could affect other erythrocyte metabolic pathways slowing down the physiological rate of cellular senescence and result in increased activity levels of other cell-age-dependent enzymes |
| 703400 | We have shown that in the young cells only hexokinase I and II are responsible for the glucose phosphorylation, while in the old cells another glucose phosphorylating activity, more evident at high glucose concentration, is also present |
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