HCSGD entry for NT5C

1. General information

Official gene symbolNT5C
Entrez ID30833
Gene full name5', 3'-nucleotidase, cytosolic
Other gene symbolsDNT DNT1 P5N2 PN-I PN-II UMPH2 cdN dNT-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006144Purine nucleobase metabolic processTASbiological_process
GO:0006195Purine nucleotide catabolic processTASbiological_process
GO:0006206Pyrimidine nucleobase metabolic processTASbiological_process
GO:0008252Nucleotidase activityIDAmolecular_function
GO:00082535'-nucleotidase activityEXP IEAmolecular_function
GO:0009223Pyrimidine deoxyribonucleotide catabolic processIDAbiological_process
GO:0009264Deoxyribonucleotide catabolic processIEAbiological_process
GO:0016311DephosphorylationIDAbiological_process
GO:0016791Phosphatase activityIEAmolecular_function
GO:0019103Pyrimidine nucleotide bindingIDAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046135Pyrimidine nucleoside catabolic processTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0055086Nucleobase-containing small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.55497785420.19630800880.99999024730.8581669324

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1418089584
GSE13712_SHEARUp1.0261557899
GSE13712_STATICUp0.5078592303
GSE19018Up0.0830092916
GSE19899_A1Up0.0211291400
GSE19899_A2Up0.0635009316
PubMed_21979375_A1Up0.0923108383
PubMed_21979375_A2Down-0.6682171491
GSE35957Down-0.2917232710
GSE36640Down-0.0544723148
GSE54402Up0.1445020899
GSE9593Up0.0776879520
GSE43922Up0.0330304205
GSE24585Down-0.1392305620
GSE37065Down-0.2020270257
GSE28863_A1Up0.0471817076
GSE28863_A2Down-0.4135262218
GSE28863_A3Up0.0490822286
GSE28863_A4Down-0.0453527693
GSE48662Down-0.3950369763

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-320aMIMAT0000510MIRT044494CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24750067METHODS: We evaluated a series of GNT (n = 31 gangliogliomas, GG and n = 30 dysembryoplastic neuroepithelial tumours, DNT)
24750067RESULTS: Both GG and DNT specimens contained caspase-3-positive cells
24750067Expression of APP, DR6, pTau (in GG and DNT) and caspase-3 (in GG) positively correlated with duration of epilepsy
17686517A girl with congenital dysgranulopoietic neutropenia (CDN) and her non-neutropenic mother with aphthae (A) were investigated
17686517We think that increased apoptosis and rapid cell senescence of leukocytes underlies the pathophysiology of CDN
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