HCSGD entry for HGD
1. General information
| Official gene symbol | HGD |
|---|---|
| Entrez ID | 3081 |
| Gene full name | homogentisate 1,2-dioxygenase |
| Other gene symbols | AKU HGO |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004411 | Homogentisate 1,2-dioxygenase activity | EXP IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006559 | L-phenylalanine catabolic process | IEA TAS | biological_process |
| GO:0006570 | Tyrosine metabolic process | IEA | biological_process |
| GO:0006572 | Tyrosine catabolic process | IEA | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5444925383 | 0.8562831351 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0831159252 |
| GSE13712_SHEAR | Up | 0.0053308031 |
| GSE13712_STATIC | Up | 0.1420148580 |
| GSE19018 | Up | 0.0890994734 |
| GSE19899_A1 | Up | 0.0248621810 |
| GSE19899_A2 | Up | 0.2409257158 |
| PubMed_21979375_A1 | Up | 0.0168727115 |
| PubMed_21979375_A2 | Up | 0.1406707137 |
| GSE35957 | Up | 0.0003251251 |
| GSE36640 | Up | 0.1503754625 |
| GSE54402 | Down | -0.0055043156 |
| GSE9593 | Down | -0.0204602509 |
| GSE43922 | Up | 0.0136828369 |
| GSE24585 | Down | -0.3449491502 |
| GSE37065 | Down | -0.0005993415 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.1817530902 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018123 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029700 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21363920 | Tumorigenesis in this setting is associated with telomere shortening that can be observed in the nondysplastic epithelium of UC patients with high-grade dysplasia (HGD) or cancer (UC progressors) |
| 21363920 | Short telomeres and increased DNA damage, senescence, and infiltrating leukocytes were observed in biopsies located less than 10 cm from HGD or cancer |
| 21363920 | Low-grade dysplasia (LGD) had the shortest telomeres along with the highest levels of senescence and infiltrating leukocytes, whereas HGD biopsies showed the opposite pattern |
| 21363920 | The expression of p16 and p53 was low in nondysplastic biopsies but progressively increased in LGD and HGD |
| 21363920 | Our findings argue that senescence acts as a tumor suppressor mechanism that is abrogated during the transition from LGD to HGD in UC |
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