HCSGD entry for NCKAP1L

1. General information

Official gene symbolNCKAP1L
Entrez ID3071
Gene full nameNCK-associated protein 1-like
Other gene symbolsHEM1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001782B cell homeostasisISSbiological_process
GO:0002262Myeloid cell homeostasisISSbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolIDAcellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0006461Protein complex assemblyISSbiological_process
GO:0006935ChemotaxisIDAbiological_process
GO:0016020MembraneTAScellular_component
GO:0030011Maintenance of cell polarityIMPbiological_process
GO:0030295Protein kinase activator activityIMPmolecular_function
GO:0030593Neutrophil chemotaxisIDAbiological_process
GO:0030675Rac GTPase activator activityIMPmolecular_function
GO:0030838Positive regulation of actin filament polymerizationIMPbiological_process
GO:0030866Cortical actin cytoskeleton organizationIMPbiological_process
GO:0030890Positive regulation of B cell proliferationIMPbiological_process
GO:0031209SCAR complexIDAcellular_component
GO:0032320Positive regulation of Ras GTPase activityIMPbiological_process
GO:0032321Positive regulation of Rho GTPase activityIMPbiological_process
GO:0032403Protein complex bindingIDAmolecular_function
GO:0032700Negative regulation of interleukin-17 productionISSbiological_process
GO:0032715Negative regulation of interleukin-6 productionISSbiological_process
GO:0032855Positive regulation of Rac GTPase activityIMPbiological_process
GO:0033630Positive regulation of cell adhesion mediated by integrinISSbiological_process
GO:0035509Negative regulation of myosin-light-chain-phosphatase activityIMPbiological_process
GO:0042102Positive regulation of T cell proliferationISSbiological_process
GO:0042327Positive regulation of phosphorylationIMPbiological_process
GO:0042493Response to drugIMPbiological_process
GO:0043029T cell homeostasisISSbiological_process
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043085Positive regulation of catalytic activityIMPbiological_process
GO:0043372Positive regulation of CD4-positive, alpha-beta T cell differentiationISSbiological_process
GO:0043378Positive regulation of CD8-positive, alpha-beta T cell differentiationISSbiological_process
GO:0043547Positive regulation of GTPase activityIMPbiological_process
GO:0045579Positive regulation of B cell differentiationISSbiological_process
GO:0045588Positive regulation of gamma-delta T cell differentiationISSbiological_process
GO:0045621Positive regulation of lymphocyte differentiationISSbiological_process
GO:0045648Positive regulation of erythrocyte differentiationISSbiological_process
GO:0045859Regulation of protein kinase activityIMPbiological_process
GO:0045860Positive regulation of protein kinase activityIMPbiological_process
GO:0048821Erythrocyte developmentIEPbiological_process
GO:0050853B cell receptor signaling pathwayIMPbiological_process
GO:0060100Positive regulation of phagocytosis, engulfmentISSbiological_process
GO:0070358Actin polymerization-dependent cell motilityIMPbiological_process
GO:0090023Positive regulation of neutrophil chemotaxisISSbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.74432211920.64424292770.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0186819142
GSE13712_SHEARUp0.0833418680
GSE13712_STATICUp0.0002348343
GSE19018Up0.0333858096
GSE19899_A1Up0.0805850132
GSE19899_A2Up0.2369824274
PubMed_21979375_A1Up0.1900608051
PubMed_21979375_A2Down-0.1141819205
GSE35957Up0.0610745571
GSE36640Up0.0913714817
GSE54402Up0.0358532584
GSE9593Down-0.0167618210
GSE43922Up0.0046012380
GSE24585Up0.2672485234
GSE37065Down-0.0290290950
GSE28863_A1Down-0.4119439421
GSE28863_A2Down-0.3293509349
GSE28863_A3Up0.2079797362
GSE28863_A4Down-0.0378090744
GSE48662Down-0.0163706540

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.