HCSGD entry for HELLS
1. General information
| Official gene symbol | HELLS |
|---|---|
| Entrez ID | 3070 |
| Gene full name | helicase, lymphoid-specific |
| Other gene symbols | LSH PASG SMARCA6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000775 | Chromosome, centromeric region | ISS | cellular_component |
| GO:0001655 | Urogenital system development | IEA | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0004386 | Helicase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005721 | Centromeric heterochromatin | IEA ISS | cellular_component |
| GO:0006346 | Methylation-dependent chromatin silencing | IEA ISS | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | ISS | biological_process |
| GO:0010216 | Maintenance of DNA methylation | IEA ISS | biological_process |
| GO:0031508 | Centromeric heterochromatin assembly | IEA ISS | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IEA | biological_process |
| GO:0046651 | Lymphocyte proliferation | IEA ISS | biological_process |
| GO:2001243 | Negative regulation of intrinsic apoptotic signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7589162608 | 0.0002845333 | 0.9999902473 | 0.0311037344 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6478790998 |
| GSE13712_SHEAR | Down | -0.2272697718 |
| GSE13712_STATIC | Down | -0.0065764098 |
| GSE19018 | Down | -0.3842412832 |
| GSE19899_A1 | Down | -0.8286129999 |
| GSE19899_A2 | Down | -3.5574598420 |
| PubMed_21979375_A1 | Down | -1.7706370487 |
| PubMed_21979375_A2 | Down | -3.2669331127 |
| GSE35957 | Down | -1.7736189535 |
| GSE36640 | Down | -3.2921863829 |
| GSE54402 | Down | -0.4680610481 |
| GSE9593 | Down | -1.0069762605 |
| GSE43922 | Down | -1.5921198468 |
| GSE24585 | Up | 0.0358876971 |
| GSE37065 | Down | -0.4415760834 |
| GSE28863_A1 | Up | 0.5663816051 |
| GSE28863_A2 | Up | 1.8008298053 |
| GSE28863_A3 | Up | 0.0951995833 |
| GSE28863_A4 | Up | 0.2845608980 |
| GSE48662 | Down | -0.9367149471 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | MIRT004361 | Luciferase reporter assay | Functional MTI | 18823940 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016323 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022243 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032248 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036852 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039180 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039720 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18948754 | Stable knockdown of PASG enhances DNA demethylation but does not accelerate cellular senescence in TIG-7 human fibroblasts |
| 18948754 | In this study, we retrovirally transduced TIG-7 human fibroblasts with a shRNA against PASG and compared the rate of change in DNA methylation as well as the replicative life-span to control cells under low (3%) and ambient (20%) oxygen |
| 18948754 | Expression of PASG protein was decreased by approximately 80% compared to control cells following transduction of PASG shRNA gene |
| 18948754 | However, decreased PASG expression did not shorten the replicative life-span of TIG-7 cells |
| 18948754 | While knockout of PASG during development results in genomic hypomethylation and premature senescence, our results show that while downregulation of PASG expression in a somatic cell also leads to DNA hypomethylation, there is no associated senescent phenotype |
| 18948754 | These results suggest differences in cellular consequences of hypomethylation mediated by PASG during development compared to that in somatic cells |
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