HCSGD entry for HDAC2


1. General information

Official gene symbolHDAC2
Entrez ID3066
Gene full namehistone deacetylase 2
Other gene symbolsHD2 RPD3 YAF1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEA IMPbiological_process
GO:0000790Nuclear chromatinIEAcellular_component
GO:0000792HeterochromatinIEAcellular_component
GO:0001047Core promoter bindingIEAmolecular_function
GO:0001103RNA polymerase II repressing transcription factor bindingIPImolecular_function
GO:0003682Chromatin bindingISSmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0004407Histone deacetylase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005657Replication forkIEAcellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005737CytoplasmTAScellular_component
GO:0006338Chromatin remodelingICbiological_process
GO:0006344Maintenance of chromatin silencingIMPbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008284Positive regulation of cell proliferationIEA IMPbiological_process
GO:0009913Epidermal cell differentiationIEA ISSbiological_process
GO:0010870Positive regulation of receptor biosynthetic processIMPbiological_process
GO:0010977Negative regulation of neuron projection developmentIEA ISSbiological_process
GO:0016358Dendrite developmentIEA ISSbiological_process
GO:0016575Histone deacetylationIMPbiological_process
GO:0016580Sin3 complexIDAcellular_component
GO:0016581NuRD complexIDAcellular_component
GO:0017053Transcriptional repressor complexIEAcellular_component
GO:0019899Enzyme bindingIEA IPImolecular_function
GO:0021766Hippocampus developmentIEAbiological_process
GO:0031072Heat shock protein bindingIEAmolecular_function
GO:0031490Chromatin DNA bindingIEAmolecular_function
GO:0032041NAD-dependent histone deacetylase activity (H3-K14 specific)IEAmolecular_function
GO:0032967Positive regulation of collagen biosynthetic processICbiological_process
GO:0033558Protein deacetylase activityIMPmolecular_function
GO:0034605Cellular response to heatIEAbiological_process
GO:0035098ESC/E(Z) complexIDAcellular_component
GO:0042220Response to cocaineIEAbiological_process
GO:0042475Odontogenesis of dentin-containing toothIEA ISSbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042733Embryonic digit morphogenesisIEA ISSbiological_process
GO:0043066Negative regulation of apoptotic processIEA ISSbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIMPbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0045347Negative regulation of MHC class II biosynthetic processICbiological_process
GO:0045786Negative regulation of cell cycleTASbiological_process
GO:0045862Positive regulation of proteolysisIMPbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIC IMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedICbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0046969NAD-dependent histone deacetylase activity (H3-K9 specific)IEAmolecular_function
GO:0046970NAD-dependent histone deacetylase activity (H4-K16 specific)IEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048714Positive regulation of oligodendrocyte differentiationIEAbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIEAbiological_process
GO:0051896Regulation of protein kinase B signalingIEAbiological_process
GO:0055013Cardiac muscle cell developmentIEAbiological_process
GO:0060044Negative regulation of cardiac muscle cell proliferationIEAbiological_process
GO:0060297Regulation of sarcomere organizationIEAbiological_process
GO:0060789Hair follicle placode formationIEA ISSbiological_process
GO:0061029Eyelid development in camera-type eyeIEA ISSbiological_process
GO:0061198Fungiform papilla formationIEA ISSbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIEAbiological_process
GO:0090311Regulation of protein deacetylationIEAbiological_process
GO:0097372NAD-dependent histone deacetylase activity (H3-K18 specific)IEAmolecular_function
GO:2001243Negative regulation of intrinsic apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.88450833180.19330068010.99999024730.8523818395

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1303932193
GSE13712_SHEARUp0.0004057137
GSE13712_STATICDown-0.0860591730
GSE19018Down-0.2634660093
GSE19899_A1Up0.0292118140
GSE19899_A2Down-0.1385669921
PubMed_21979375_A1Up0.0365047506
PubMed_21979375_A2Down-0.1954277179
GSE35957Down-0.2773755420
GSE36640Down-0.7147694487
GSE54402Down-0.0212841182
GSE9593Down-0.4215100288
GSE43922Down-0.0453805206
GSE24585Down-0.0498060437
GSE37065Up0.0129908713
GSE28863_A1Up0.1521579883
GSE28863_A2Up0.4499638001
GSE28863_A3Up0.2745579210
GSE28863_A4Down-0.1396828383
GSE48662Down-0.1706391566

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL1213490CHEMBL19379Q92769
CHEMBL513568CHEMBL19379Q92769
CHEMBL236902CHEMBL19379Q92769
CHEMBL1631918CHEMBL19379Q92769
CHEMBL98CHEMBL19379Q92769
CHEMBL255805CHEMBL19379Q92769
CHEMBL217651CHEMBL19379Q92769
CHEMBL356066CHEMBL19379Q92769
CHEMBL609583CHEMBL19379Q92769
CHEMBL511432CHEMBL19379Q92769
CHEMBL484073CHEMBL19379Q92769
CHEMBL146250CHEMBL19379Q92769
CHEMBL1801238CHEMBL19379Q92769
CHEMBL216641CHEMBL19379Q92769
CHEMBL1631915CHEMBL19379Q92769
CHEMBL1631917CHEMBL19379Q92769
CHEMBL484489CHEMBL19379Q92769
CHEMBL98CHEMBL19379Q92769
CHEMBL1923808CHEMBL19379Q92769
CHEMBL1631913CHEMBL19379Q92769
CHEMBL256440CHEMBL19379Q92769
CHEMBL1631910CHEMBL19379Q92769
CHEMBL1631916CHEMBL19379Q92769
CHEMBL471824CHEMBL19379Q92769
CHEMBL468527CHEMBL19379Q92769
CHEMBL98CHEMBL19379Q92769
CHEMBL236678CHEMBL19379Q92769
CHEMBL598797CHEMBL19379Q92769
CHEMBL1914708CHEMBL19379Q92769
CHEMBL98CHEMBL19379Q92769
CHEMBL99CHEMBL19379Q92769
CHEMBL1631911CHEMBL19379Q92769
CHEMBL466644CHEMBL19379Q92769
CHEMBL1631912CHEMBL19379Q92769
CHEMBL98CHEMBL19379Q92769
CHEMBL485514CHEMBL19379Q92769
CHEMBL511715CHEMBL19379Q92769
CHEMBL594544CHEMBL19379Q92769
CHEMBL511797CHEMBL19379Q92769
CHEMBL98CHEMBL19379Q92769
CHEMBL99CHEMBL19379Q92769
CHEMBL98CHEMBL19379Q92769
CHEMBL490018CHEMBL19379Q92769
CHEMBL99CHEMBL19379Q92769
CHEMBL251144CHEMBL19379Q92769
CHEMBL1914702CHEMBL19379Q92769
CHEMBL251011CHEMBL19379Q92769
CHEMBL99CHEMBL19379Q92769
CHEMBL1801250CHEMBL19379Q92769
CHEMBL27759CHEMBL19379Q92769
CHEMBL469134CHEMBL19379Q92769
CHEMBL269935CHEMBL19379Q92769
CHEMBL1631914CHEMBL19379Q92769
CHEMBL1213490CHEMBL19379Q92769
CHEMBL482358CHEMBL19379Q92769
CHEMBL405072CHEMBL19379Q92769
CHEMBL140525CHEMBL19379Q92769
CHEMBL1097278CHEMBL19379Q92769
CHEMBL251010CHEMBL19379Q92769
CHEMBL235411CHEMBL19379Q92769
CHEMBL1767043CHEMBL19379Q92769
CHEMBL1097745CHEMBL19379Q92769
CHEMBL539156CHEMBL19379Q92769
CHEMBL27759CHEMBL19379Q92769
CHEMBL556532CHEMBL19379Q92769
CHEMBL356769CHEMBL19379Q92769
CHEMBL14227CHEMBL19379Q92769
CHEMBL1095096CHEMBL19379Q92769
CHEMBL272980CHEMBL19379Q92769
CHEMBL271741CHEMBL19379Q92769
CHEMBL271741CHEMBL19379Q92769
CHEMBL481719CHEMBL19379Q92769
CHEMBL1099078CHEMBL19379Q92769
CHEMBL1812335CHEMBL19379Q92769
CHEMBL1097748CHEMBL19379Q92769
CHEMBL402719CHEMBL19379Q92769
CHEMBL236060CHEMBL19379Q92769
CHEMBL98CHEMBL19379Q92769
CHEMBL55895CHEMBL19379Q92769
CHEMBL405072CHEMBL19379Q92769
CHEMBL471043CHEMBL19379Q92769
CHEMBL551486CHEMBL19379Q92769
CHEMBL343717CHEMBL19379Q92769
CHEMBL561212CHEMBL19379Q92769
CHEMBL99CHEMBL19379Q92769
CHEMBL353581CHEMBL19379Q92769
CHEMBL471042CHEMBL19379Q92769
CHEMBL481538CHEMBL19379Q92769
CHEMBL556332CHEMBL19379Q92769
CHEMBL472631CHEMBL19379Q92769
CHEMBL399388CHEMBL19379Q92769
CHEMBL249198CHEMBL19379Q92769
CHEMBL235674CHEMBL19379Q92769
CHEMBL408513CHEMBL19379Q92769
CHEMBL1096397CHEMBL19379Q92769
CHEMBL1767029CHEMBL19379Q92769
CHEMBL248798CHEMBL19379Q92769
CHEMBL98CHEMBL19379Q92769
CHEMBL1096072CHEMBL19379Q92769
CHEMBL1097746CHEMBL19379Q92769
CHEMBL337584CHEMBL19379Q92769
CHEMBL320497CHEMBL19379Q92769
CHEMBL211625CHEMBL19379Q92769
CHEMBL400482CHEMBL19379Q92769
CHEMBL521431CHEMBL19379Q92769
CHEMBL479842CHEMBL19379Q92769
CHEMBL1097746CHEMBL19379Q92769
CHEMBL1097747CHEMBL19379Q92769
CHEMBL1098337CHEMBL19379Q92769
CHEMBL1095095CHEMBL19379Q92769
CHEMBL1767046CHEMBL19379Q92769
CHEMBL251406CHEMBL19379Q92769
CHEMBL541239CHEMBL19379Q92769
CHEMBL519943CHEMBL19379Q92769
CHEMBL516600CHEMBL19379Q92769
CHEMBL109CHEMBL19379Q92769
CHEMBL336935CHEMBL19379Q92769
CHEMBL402718CHEMBL19379Q92769
CHEMBL481802CHEMBL19379Q92769
CHEMBL96051CHEMBL19379Q92769
CHEMBL480729CHEMBL19379Q92769
CHEMBL1767044CHEMBL19379Q92769
CHEMBL518957CHEMBL19379Q92769
CHEMBL98CHEMBL19379Q92769
CHEMBL557066CHEMBL19379Q92769
CHEMBL237584CHEMBL19379Q92769
CHEMBL1469CHEMBL19379Q92769
CHEMBL1213459CHEMBL19379Q92769
CHEMBL1095096CHEMBL19379Q92769
CHEMBL98CHEMBL19379Q92769
CHEMBL1097745CHEMBL19379Q92769
CHEMBL1213492CHEMBL19379Q92769
CHEMBL141909CHEMBL19379Q92769
CHEMBL1096397CHEMBL19379Q92769
CHEMBL470843CHEMBL19379Q92769
CHEMBL552750CHEMBL19379Q92769
CHEMBL1097063CHEMBL19379Q92769
CHEMBL139192CHEMBL19379Q92769
CHEMBL1213490CHEMBL19379Q92769
CHEMBL1097278CHEMBL19379Q92769
CHEMBL250005CHEMBL19379Q92769
CHEMBL251009CHEMBL19379Q92769
CHEMBL235842CHEMBL19379Q92769
CHEMBL481726CHEMBL19379Q92769
CHEMBL392747CHEMBL19379Q92769
CHEMBL561209CHEMBL19379Q92769
CHEMBL272980CHEMBL19379Q92769
CHEMBL235413CHEMBL19379Q92769
CHEMBL236061CHEMBL19379Q92769
CHEMBL1099078CHEMBL19379Q92769
CHEMBL1097651CHEMBL19379Q92769
CHEMBL141082CHEMBL19379Q92769
CHEMBL356066CHEMBL19379Q92769
CHEMBL1767039CHEMBL19379Q92769
CHEMBL139193CHEMBL19379Q92769
CHEMBL235191CHEMBL19379Q92769
CHEMBL538710CHEMBL19379Q92769
CHEMBL1097063CHEMBL19379Q92769
CHEMBL137875CHEMBL19379Q92769
CHEMBL98CHEMBL19379Q92769
CHEMBL1096398CHEMBL19379Q92769
CHEMBL1097747CHEMBL19379Q92769
CHEMBL251206CHEMBL19379Q92769
CHEMBL1097651CHEMBL19379Q92769
CHEMBL1097744CHEMBL19379Q92769
CHEMBL430060CHEMBL19379Q92769
CHEMBL565140CHEMBL19379Q92769
CHEMBL1096398CHEMBL19379Q92769
CHEMBL555906CHEMBL19379Q92769
CHEMBL1094108CHEMBL19379Q92769
CHEMBL551151CHEMBL19379Q92769
CHEMBL1098337CHEMBL19379Q92769
CHEMBL481018CHEMBL19379Q92769
CHEMBL1094108CHEMBL19379Q92769
CHEMBL1096072CHEMBL19379Q92769
CHEMBL1213457CHEMBL19379Q92769
CHEMBL1095412CHEMBL19379Q92769
CHEMBL235210CHEMBL19379Q92769
CHEMBL393242CHEMBL19379Q92769
CHEMBL235191CHEMBL19379Q92769
CHEMBL471041CHEMBL19379Q92769
CHEMBL99CHEMBL19379Q92769
CHEMBL483254CHEMBL19379Q92769
CHEMBL99CHEMBL19379Q92769
CHEMBL141885CHEMBL19379Q92769
CHEMBL1213458CHEMBL19379Q92769
CHEMBL27759CHEMBL19379Q92769
CHEMBL356066CHEMBL19379Q92769
CHEMBL98CHEMBL19379Q92769
CHEMBL1095095CHEMBL19379Q92769
CHEMBL538713CHEMBL19379Q92769
CHEMBL481718CHEMBL19379Q92769
CHEMBL55895CHEMBL19379Q92769
CHEMBL235192CHEMBL19379Q92769
CHEMBL98CHEMBL19379Q92769
CHEMBL1672332CHEMBL19379Q92769
CHEMBL1095412CHEMBL19379Q92769
CHEMBL1213491CHEMBL19379Q92769
CHEMBL1097748CHEMBL19379Q92769
CHEMBL467792CHEMBL19378Q92769
CHEMBL489332CHEMBL19378Q92769
CHEMBL1830396CHEMBL19378Q92769
CHEMBL1830397CHEMBL19378Q92769
CHEMBL1088736CHEMBL19378Q92769
CHEMBL98CHEMBL19378Q92769
CHEMBL1091474CHEMBL19378Q92769
CHEMBL98CHEMBL19378Q92769
CHEMBL399494CHEMBL19378Q92769
CHEMBL511749CHEMBL19378Q92769
CHEMBL27759CHEMBL19378Q92769
CHEMBL98CHEMBL19378Q92769
CHEMBL466215CHEMBL19378Q92769
CHEMBL468513CHEMBL19378Q92769
CHEMBL483254CHEMBL19378Q92769
CHEMBL468842CHEMBL19378Q92769
CHEMBL467793CHEMBL19378Q92769
CHEMBL469274CHEMBL19378Q92769
CHEMBL483892CHEMBL19378Q92769
CHEMBL483495CHEMBL19378Q92769
CHEMBL491316CHEMBL19378Q92769
CHEMBL470225CHEMBL19378Q92769
CHEMBL519668CHEMBL19378Q92769
CHEMBL1088734CHEMBL19378Q92769
CHEMBL99CHEMBL19378Q92769
CHEMBL483693CHEMBL19378Q92769
CHEMBL1094709CHEMBL19378Q92769
CHEMBL519491CHEMBL19378Q92769
CHEMBL387924CHEMBL19378Q92769
CHEMBL519746CHEMBL19378Q92769
CHEMBL491316CHEMBL19378Q92769
CHEMBL356769CHEMBL19378Q92769
CHEMBL227118CHEMBL19378Q92769
CHEMBL488747CHEMBL19378Q92769
CHEMBL487106CHEMBL19378Q92769
CHEMBL520056CHEMBL19378Q92769
CHEMBL446512CHEMBL19378Q92769
CHEMBL227119CHEMBL19378Q92769
CHEMBL483893CHEMBL19378Q92769
CHEMBL519668CHEMBL19378Q92769
CHEMBL440018CHEMBL19378Q92769
CHEMBL487741CHEMBL19378Q92769
CHEMBL1093335CHEMBL19378Q92769
CHEMBL1830420CHEMBL19378Q92769
CHEMBL1830537CHEMBL19378Q92769
CHEMBL227170CHEMBL19378Q92769
CHEMBL467998CHEMBL19378Q92769
CHEMBL98CHEMBL19378Q92769
CHEMBL407959CHEMBL19378Q92769
CHEMBL483494CHEMBL19378Q92769
CHEMBL1830424CHEMBL19378Q92769
CHEMBL99CHEMBL19378Q92769
CHEMBL98CHEMBL19378Q92769
CHEMBL407959CHEMBL19378Q92769
CHEMBL261735CHEMBL19378Q92769
CHEMBL1083439CHEMBL19378Q92769
CHEMBL27759CHEMBL19378Q92769
CHEMBL1093033CHEMBL19378Q92769
CHEMBL469275CHEMBL19378Q92769
CHEMBL1083086CHEMBL19378Q92769
CHEMBL99CHEMBL19378Q92769
CHEMBL1094710CHEMBL19378Q92769
CHEMBL487943CHEMBL19378Q92769
CHEMBL99CHEMBL19378Q92769
CHEMBL406927CHEMBL19378Q92769
CHEMBL98CHEMBL19378Q92769
CHEMBL487107CHEMBL19378Q92769
CHEMBL1094707CHEMBL19378Q92769
CHEMBL460963CHEMBL19378Q92769
CHEMBL98CHEMBL19378Q92769
CHEMBL99CHEMBL19378Q92769
CHEMBL1830536CHEMBL19378Q92769
CHEMBL235674CHEMBL19378Q92769
CHEMBL430060CHEMBL19378Q92769
CHEMBL253868CHEMBL19378Q92769
CHEMBL1091475CHEMBL19378Q92769
CHEMBL468841CHEMBL19378Q92769
CHEMBL389688CHEMBL19378Q92769
CHEMBL513160CHEMBL19378Q92769
CHEMBL98CHEMBL19378Q92769
CHEMBL180911CHEMBL19378Q92769
CHEMBL487533CHEMBL19378Q92769
CHEMBL398420CHEMBL19378Q92769
CHEMBL236902CHEMBL19378Q92769
CHEMBL400721CHEMBL19378Q92769
CHEMBL272401CHEMBL19378Q92769
CHEMBL487742CHEMBL19378Q92769
CHEMBL178456CHEMBL19378Q92769
CHEMBL98CHEMBL19378Q92769
CHEMBL98CHEMBL19378Q92769
CHEMBL27759CHEMBL19378Q92769
CHEMBL408513CHEMBL19378Q92769
CHEMBL1830422CHEMBL19378Q92769
CHEMBL468595CHEMBL19378Q92769
CHEMBL389687CHEMBL19378Q92769
CHEMBL1830392CHEMBL19378Q92769
CHEMBL227120CHEMBL19378Q92769
CHEMBL1957459CHEMBL19378Q92769
CHEMBL235842CHEMBL19378Q92769
CHEMBL396097CHEMBL19378Q92769
CHEMBL1800241CHEMBL19378Q92769
CHEMBL269935CHEMBL19378Q92769
CHEMBL1957458CHEMBL19378Q92769
CHEMBL235210CHEMBL19378Q92769
CHEMBL1771487CHEMBL19378Q92769
CHEMBL235842CHEMBL19378Q92769
CHEMBL1096981CHEMBL19378Q92769
CHEMBL27759CHEMBL19378Q92769
CHEMBL1771485CHEMBL19378Q92769
CHEMBL1771486CHEMBL19378Q92769
CHEMBL1957463CHEMBL19378Q92769
CHEMBL1164244CHEMBL19378Q92769
CHEMBL1668018CHEMBL19378Q92769
CHEMBL96051CHEMBL19378Q92769
CHEMBL235842CHEMBL19378Q92769
CHEMBL1243289CHEMBL19378Q92769
CHEMBL272980CHEMBL19378Q92769
CHEMBL27759CHEMBL19378Q92769
CHEMBL251819CHEMBL19378Q92769
CHEMBL99CHEMBL19378Q92769
CHEMBL98CHEMBL19378Q92769
CHEMBL99CHEMBL19378Q92769
CHEMBL99CHEMBL19378Q92769
CHEMBL1643325CHEMBL19378Q92769
CHEMBL1957464CHEMBL19378Q92769
CHEMBL405072CHEMBL19378Q92769
CHEMBL1096982CHEMBL19378Q92769
CHEMBL1243261CHEMBL19378Q92769
CHEMBL98CHEMBL19378Q92769
CHEMBL1163778CHEMBL19378Q92769
CHEMBL1164671CHEMBL19378Q92769
CHEMBL402363CHEMBL19378Q92769
CHEMBL271741CHEMBL19378Q92769
CHEMBL1800383CHEMBL19378Q92769
CHEMBL1771315CHEMBL19378Q92769
CHEMBL356066CHEMBL19378Q92769
CHEMBL271949CHEMBL19378Q92769
CHEMBL1771484CHEMBL19378Q92769
CHEMBL1643315CHEMBL19378Q92769
CHEMBL272980CHEMBL19378Q92769
CHEMBL1800375CHEMBL19378Q92769
CHEMBL437029CHEMBL19378Q92769
CHEMBL98CHEMBL19378Q92769
CHEMBL27759CHEMBL19378Q92769
CHEMBL1164992CHEMBL19378Q92769
CHEMBL1643308CHEMBL19378Q92769
CHEMBL98CHEMBL19378Q92769
CHEMBL98CHEMBL19378Q92769
CHEMBL407420CHEMBL19378Q92769
CHEMBL481805CHEMBL19378Q92769
CHEMBL1164212CHEMBL19378Q92769
CHEMBL98CHEMBL19377Q92769
CHEMBL189912CHEMBL19377Q92769
CHEMBL570499CHEMBL19377Q92769
CHEMBL571802CHEMBL19377Q92769
CHEMBL568586CHEMBL19377Q92769
CHEMBL567972CHEMBL19377Q92769
CHEMBL578209CHEMBL19377Q92769
CHEMBL567971CHEMBL19377Q92769
CHEMBL570492CHEMBL19377Q92769
CHEMBL570280CHEMBL19377Q92769
CHEMBL570279CHEMBL19377Q92769
CHEMBL566697CHEMBL19377Q92769
CHEMBL98CHEMBL19377Q92769
CHEMBL567155CHEMBL19377Q92769
CHEMBL586060CHEMBL19377Q92769
CHEMBL585905CHEMBL19377Q92769
CHEMBL571358CHEMBL19377Q92769
CHEMBL568184CHEMBL19377Q92769
CHEMBL568886CHEMBL19377Q92769
CHEMBL570050CHEMBL19377Q92769
CHEMBL568185CHEMBL19377Q92769
CHEMBL583409CHEMBL19377Q92769
CHEMBL576109CHEMBL19377Q92769
CHEMBL1793944CHEMBL19375Q92769
CHEMBL301223CHEMBL19375Q92769
CHEMBL1793819CHEMBL19375Q92769
CHEMBL339534CHEMBL19375Q92769
CHEMBL141502CHEMBL19375Q92769
CHEMBL82989CHEMBL19375Q92769
CHEMBL127846CHEMBL19375Q92769
CHEMBL56040CHEMBL19375Q92769
CHEMBL55864CHEMBL19375Q92769
CHEMBL146446CHEMBL19375Q92769
CHEMBL56770CHEMBL19375Q92769
CHEMBL99661CHEMBL19375Q92769
CHEMBL189497CHEMBL19375Q92769
CHEMBL421934CHEMBL19375Q92769
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CHEMBL336935CHEMBL19375Q92769
CHEMBL195940CHEMBL19375Q92769
CHEMBL117916CHEMBL19375Q92769
CHEMBL116023CHEMBL19375Q92769
CHEMBL126355CHEMBL19375Q92769
CHEMBL321283CHEMBL19375Q92769
CHEMBL1836042CHEMBL19375Q92769
CHEMBL537640CHEMBL19375Q92769
CHEMBL199665CHEMBL19375Q92769
CHEMBL195581CHEMBL19375Q92769
CHEMBL112211CHEMBL19375Q92769
CHEMBL146251CHEMBL19375Q92769
CHEMBL193959CHEMBL19375Q92769
CHEMBL1213490CHEMBL19375Q92769
CHEMBL98CHEMBL19375Q92769
CHEMBL371212CHEMBL19375Q92769
CHEMBL383587CHEMBL19375Q92769
CHEMBL149249CHEMBL19375Q92769
CHEMBL57107CHEMBL19375Q92769
CHEMBL99CHEMBL19374Q92769
CHEMBL320323CHEMBL19374Q92769
CHEMBL325675CHEMBL19374Q92769
CHEMBL113159CHEMBL19374Q92769
CHEMBL415533CHEMBL19374Q92769
CHEMBL112105CHEMBL19374Q92769
CHEMBL109796CHEMBL19374Q92769
CHEMBL370253CHEMBL19374Q92769
CHEMBL145099CHEMBL19374Q92769
CHEMBL356769CHEMBL19374Q92769
CHEMBL98CHEMBL19374Q92769
CHEMBL142441CHEMBL19374Q92769
CHEMBL415533CHEMBL19374Q92769
CHEMBL189381CHEMBL19374Q92769
CHEMBL192533CHEMBL19374Q92769
CHEMBL112311CHEMBL19374Q92769
CHEMBL321283CHEMBL19374Q92769
CHEMBL321105CHEMBL19374Q92769
CHEMBL192098CHEMBL19374Q92769
CHEMBL145028CHEMBL19374Q92769
CHEMBL145685CHEMBL19374Q92769
CHEMBL142441CHEMBL19374Q92769
CHEMBL325676CHEMBL19374Q92769
CHEMBL27759CHEMBL19374Q92769
CHEMBL145531CHEMBL19374Q92769
CHEMBL326433CHEMBL19374Q92769
CHEMBL192870CHEMBL19374Q92769
CHEMBL145531CHEMBL19374Q92769
CHEMBL191852CHEMBL19374Q92769
CHEMBL113421CHEMBL19374Q92769
CHEMBL101167CHEMBL19374Q92769
CHEMBL99CHEMBL19374Q92769
CHEMBL364970CHEMBL19374Q92769
CHEMBL192960CHEMBL19374Q92769
CHEMBL114237CHEMBL19374Q92769
CHEMBL191089CHEMBL19374Q92769
CHEMBL99CHEMBL19374Q92769
CHEMBL365372CHEMBL19374Q92769
CHEMBL365535CHEMBL19374Q92769
CHEMBL145099CHEMBL19374Q92769
CHEMBL192199CHEMBL19374Q92769
CHEMBL324126CHEMBL19374Q92769
CHEMBL322504CHEMBL19374Q92769
CHEMBL114344CHEMBL19374Q92769
CHEMBL109654CHEMBL19374Q92769
CHEMBL332246CHEMBL19374Q92769
CHEMBL319375CHEMBL19374Q92769
CHEMBL419716CHEMBL19374Q92769
CHEMBL112234CHEMBL19374Q92769
CHEMBL371806CHEMBL19374Q92769
CHEMBL145116CHEMBL19374Q92769
CHEMBL98CHEMBL19374Q92769
CHEMBL421589CHEMBL19374Q92769
CHEMBL419758CHEMBL19374Q92769
CHEMBL111806CHEMBL19374Q92769
CHEMBL98CHEMBL19374Q92769
CHEMBL113537CHEMBL19374Q92769
CHEMBL145028CHEMBL19374Q92769
CHEMBL145685CHEMBL19374Q92769
CHEMBL145116CHEMBL19374Q92769
CHEMBL100282CHEMBL19374Q92769
CHEMBL112129CHEMBL19374Q92769
CHEMBL191623CHEMBL19374Q92769
CHEMBL112364CHEMBL19374Q92769
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  • Drugs

Name

Drug

Accession number

TheophyllineDB00277 APRD00082 | DB09359
AminophyllineDB01223 APRD00329
OxtriphyllineDB01303 -
VorinostatDB02546 EXPT02902
SB939DB05223 -
MGCD-0103DB05651 -
RomidepsinDB06176 -
PanobinostatDB06603 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-145-5pMIMAT0000437MIRT007307Luciferase reporter assayFunctional MTI23499894
hsa-miR-1MIMAT0000416MIRT023724ProteomicsFunctional MTI (Weak)18668040
hsa-miR-149-5pMIMAT0000450MIRT045549CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 8 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27373322Oxidative stress plays a key role in driving COPD-related inflammation, even in ex-smokers, and might result in activation of the proinflammatory transcription factor nuclear factor kappaB (NF-kappaB), impaired antiprotease defenses, DNA damage, cellular senescence, autoantibody generation, and corticosteroid resistance though inactivation of histone deacetylase 2
26676829The expression of HDAC2 was either silenced via short hairpin (sh)RNA or induced by transfection of plasmids expressing the HDAC2 gene in certain HCC cells
25940290OBJECTIVE: To investigate whether cigarette smoke extract (CSE) induces the senescence of skeletal muscle cells by oxidative stress-induced down-regulation of histone deacetylase 2 (HDAC2)
25940290The expressions of HDAC2 mRNA and protein were measured by real-time quantitative PCR and Western blotting, respectively
25940290RESULTS: Compared with the control group, MDA concentration and ROS activity significantly increased, the activities of SOD and GSH-Px significantly decreased, the expression of beta-galactosidase was up-regulated, and the expressions of HDAC2 mRNA and protein were down-regulated in the CSE group and the H2O2 group
25940290CONCLUSION: CSE may lead to the senescence of murine skeletal muscle cells by oxidative stress-induced down-regulation of HDAC2
22842217Histone deacetylase 2 (HDAC2) is a class I histone deacetylase that regulates various cellular processes, such as cell cycle, senescence, proliferation, differentiation, development, apoptosis, and glucocorticoid function in inhibiting inflammatory response
22842217HDAC2 has been shown to protect against DNA damage response and cellular senescence/premature aging via an epigenetic mechanism in response to oxidative stress
19818845HDAC1 is a member of the class I of histone deacetylases that also includes HDAC2, -3 and -8
17409421Histone deacetylase 2 modulates p53 transcriptional activities through regulation of p53-DNA binding activity
17409421Through the use of stable MCF7 cell lines which inducibly express short hairpin RNA targeting HDAC2, we found that HDAC2 plays important roles in the p53 pathway
17409421Importantly, we found that knockdown of HDAC2 enhanced p53-dependent trans-repression and trans-activation of a subset of target genes
11418121Histone deacetylases in replicative senescence: evidence for a senescence-specific form of HDAC-2
11418121While by anion exchange chromatography we found a single peak of activity in extracts from young cells, which coincided with the elution of both HDAC-1 and HDAC-2, in senescent cells a second peak of activity was found
11418121This second peak of activity is associated with HDAC-2 but does not contain HDAC-1
11418121These results suggest that HDAC-2 is present in at least two distinct forms, one of which is specific for senescent cells
11257101The failure to deacetylate and thus repress transcription by the Class I histone deacetylases HDAC1 and HDAC2 due to disruption of the Rb family of proteins has been firmly established as a mechanism leading to increases in growth rate and cellular proliferation
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