HCSGD entry for HCRT

1. General information

Official gene symbolHCRT
Entrez ID3060
Gene full namehypocretin (orexin) neuropeptide precursor
Other gene symbolsNRCLP1 OX PPOX
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005576Extracellular regionTAScellular_component
GO:0005791Rough endoplasmic reticulumIEAcellular_component
GO:0007200Phospholipase C-activating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIEAbiological_process
GO:0007205Protein kinase C-activating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007218Neuropeptide signaling pathwayIEAbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0008021Synaptic vesicleTAScellular_component
GO:0008156Negative regulation of DNA replicationIEAbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0030141Secretory granuleIEAcellular_component
GO:0031771Type 1 hypocretin receptor bindingIEAmolecular_function
GO:0031772Type 2 hypocretin receptor bindingIEAmolecular_function
GO:0042755Eating behaviorIEAbiological_process
GO:0043267Negative regulation of potassium ion transportIEAbiological_process
GO:0046928Regulation of neurotransmitter secretionIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0051928Positive regulation of calcium ion transportIEAbiological_process
GO:0051970Negative regulation of transmission of nerve impulseIEAbiological_process
GO:0051971Positive regulation of transmission of nerve impulseIEAbiological_process
GO:0060079Regulation of excitatory postsynaptic membrane potentialIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.45381893930.88496978840.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0561371551
GSE13712_SHEARDown-0.0694046645
GSE13712_STATICUp0.0711564367
GSE19018Up0.1042412157
GSE19899_A1Up0.0491152877
GSE19899_A2Up0.1430927167
PubMed_21979375_A1Up0.0452459500
PubMed_21979375_A2Up0.1330246237
GSE35957Up0.1014338985
GSE36640Up0.0737818723
GSE54402Down-0.0317199336
GSE9593Down-0.0607726323
GSE43922Up0.0584291588
GSE24585Down-0.0914326187
GSE37065Down-0.1607302702
GSE28863_A1Down-0.0718848443
GSE28863_A2Up0.1444800263
GSE28863_A3Up0.3819777618
GSE28863_A4Up0.1894310763
GSE48662Up0.0207250204

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Pyroglutamic AcidDB03088 EXPT00247

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.