HCSGD entry for HCLS1

1. General information

Official gene symbolHCLS1
Entrez ID3059
Gene full namehematopoietic cell-specific Lyn substrate 1
Other gene symbolsCTTNL HS1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001085RNA polymerase II transcription factor bindingIPImolecular_function
GO:0003779Actin bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA ISScellular_component
GO:0005667Transcription factor complexIDAcellular_component
GO:0005737CytoplasmIDA ISScellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006355Regulation of transcription, DNA-templatedTASbiological_process
GO:0008284Positive regulation of cell proliferationISSbiological_process
GO:0009725Response to hormoneISSbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIMPbiological_process
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030041Actin filament polymerizationIEAbiological_process
GO:0030218Erythrocyte differentiationISSbiological_process
GO:0030833Regulation of actin filament polymerizationIMPbiological_process
GO:0030854Positive regulation of granulocyte differentiationIMPbiological_process
GO:0032403Protein complex bindingIEAmolecular_function
GO:0033138Positive regulation of peptidyl-serine phosphorylationIMPbiological_process
GO:0035556Intracellular signal transductionTASbiological_process
GO:0042531Positive regulation of tyrosine phosphorylation of STAT proteinISSbiological_process
GO:0042993Positive regulation of transcription factor import into nucleusIMPbiological_process
GO:0045651Positive regulation of macrophage differentiationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIMPbiological_process
GO:0051897Positive regulation of protein kinase B signalingIMPbiological_process
GO:0071345Cellular response to cytokine stimulusIMPbiological_process
GO:2000107Negative regulation of leukocyte apoptotic processIMPbiological_process
GO:2000251Positive regulation of actin cytoskeleton reorganizationICbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00684064060.76040300520.21616630701.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3209630570
GSE13712_SHEARUp0.5291604710
GSE13712_STATICUp0.5425912506
GSE19018Down-0.1087694924
GSE19899_A1Up0.3719581679
GSE19899_A2Up3.1150280773
PubMed_21979375_A1Up1.4882847739
PubMed_21979375_A2Up0.9122828309
GSE35957Up0.7568793009
GSE36640Up0.1523580571
GSE54402Up1.3534443154
GSE9593Down-0.3910844886
GSE43922Up0.0219377356
GSE24585Down-0.0543289610
GSE37065Up0.1715430918
GSE28863_A1Down-0.0868548903
GSE28863_A2Down-0.4058108465
GSE28863_A3Up0.1943190031
GSE28863_A4Down-0.0393861642
GSE48662Down-0.3544554649

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-484MIMAT0002174MIRT041795CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.