HCSGD entry for HCK
1. General information
| Official gene symbol | HCK |
|---|---|
| Entrez ID | 3055 |
| Gene full name | hemopoietic cell kinase |
| Other gene symbols | JTK9 p59Hck p61Hck |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002522 | Leukocyte migration involved in immune response | TAS | biological_process |
| GO:0002758 | Innate immune response-activating signal transduction | TAS | biological_process |
| GO:0004713 | Protein tyrosine kinase activity | IEA IMP | molecular_function |
| GO:0004715 | Non-membrane spanning protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005764 | Lysosome | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005884 | Actin filament | IDA | cellular_component |
| GO:0005901 | Caveola | IDA | cellular_component |
| GO:0005925 | Focal adhesion | IMP | cellular_component |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0006909 | Phagocytosis | IEA | biological_process |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0007155 | Cell adhesion | TAS | biological_process |
| GO:0007229 | Integrin-mediated signaling pathway | TAS | biological_process |
| GO:0007498 | Mesoderm development | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IMP | biological_process |
| GO:0008360 | Regulation of cell shape | IMP | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | IMP | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0030133 | Transport vesicle | IEA | cellular_component |
| GO:0030838 | Positive regulation of actin filament polymerization | TAS | biological_process |
| GO:0031234 | Extrinsic component of cytoplasmic side of plasma membrane | IMP | cellular_component |
| GO:0031663 | Lipopolysaccharide-mediated signaling pathway | TAS | biological_process |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | biological_process |
| GO:0042995 | Cell projection | IEA | cellular_component |
| GO:0043066 | Negative regulation of apoptotic process | IMP | biological_process |
| GO:0043299 | Leukocyte degranulation | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045728 | Respiratory burst after phagocytosis | TAS | biological_process |
| GO:0046777 | Protein autophosphorylation | IMP | biological_process |
| GO:0050690 | Regulation of defense response to virus by virus | TAS | biological_process |
| GO:0050727 | Regulation of inflammatory response | TAS | biological_process |
| GO:0050764 | Regulation of phagocytosis | IMP | biological_process |
| GO:0050830 | Defense response to Gram-positive bacterium | IEA | biological_process |
| GO:0051090 | Regulation of sequence-specific DNA binding transcription factor activity | IMP | biological_process |
| GO:0060333 | Interferon-gamma-mediated signaling pathway | TAS | biological_process |
| GO:0071801 | Regulation of podosome assembly | IDA | biological_process |
| GO:2000251 | Positive regulation of actin cytoskeleton reorganization | IDA IMP | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0597073060 | 0.9556941910 | 0.5295000000 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.8550547443 |
| GSE13712_SHEAR | Down | -0.0049281443 |
| GSE13712_STATIC | Up | 0.0744081331 |
| GSE19018 | Up | 0.1023618266 |
| GSE19899_A1 | Up | 0.3149066694 |
| GSE19899_A2 | Down | -0.1903253557 |
| PubMed_21979375_A1 | Up | 0.0229233557 |
| PubMed_21979375_A2 | Up | 0.0466199180 |
| GSE35957 | Up | 0.1582880577 |
| GSE36640 | Up | 0.1335659365 |
| GSE54402 | Up | 0.0178102320 |
| GSE9593 | Down | -0.0735870876 |
| GSE43922 | Up | 0.0196423153 |
| GSE24585 | Up | 0.1007687229 |
| GSE37065 | Up | 0.4622611835 |
| GSE28863_A1 | Down | -0.1939363254 |
| GSE28863_A2 | Up | 0.5520830693 |
| GSE28863_A3 | Up | 0.3993534616 |
| GSE28863_A4 | Up | 0.1610188847 |
| GSE48662 | Up | 0.0833651645 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Entries Per Page
Displaying Page of
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine | DB01809 | EXPT02633 |
| Phosphonotyrosine | DB01962 | EXPT02687 |
| Quercetin | DB04216 | EXPT02732 |
| Bosutinib | DB06616 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22926520 | Expression of the SFK v-Src, Hck or Lyn together with STAT5A results in phosphorylation on Y694 and cytoplasmic retention |
| 22926520 | Upon coexpression of BCR-ABL and individual SFK the cytoplasmic retention of activated STAT5A mediated by v-Src and Hck but not Lyn is dominant over nuclear translocation induced by BCR-ABL |
Entries Per Page
Displaying Page of
