HCSGD entry for HCFC1
1. General information
| Official gene symbol | HCFC1 |
|---|---|
| Entrez ID | 3054 |
| Gene full name | host cell factor C1 (VP16-accessory protein) |
| Other gene symbols | CFF HCF-1 HCF1 HFC1 MRX3 VCAF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | ISS | biological_process |
| GO:0000123 | Histone acetyltransferase complex | IDA | cellular_component |
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | NAS | molecular_function |
| GO:0003713 | Transcription coactivator activity | IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0010628 | Positive regulation of gene expression | IDA | biological_process |
| GO:0019046 | Release from viral latency | NAS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0043025 | Neuronal cell body | IDA | cellular_component |
| GO:0043254 | Regulation of protein complex assembly | IDA | biological_process |
| GO:0043981 | Histone H4-K5 acetylation | IDA | biological_process |
| GO:0043982 | Histone H4-K8 acetylation | IDA | biological_process |
| GO:0043984 | Histone H4-K16 acetylation | IDA | biological_process |
| GO:0043995 | Histone acetyltransferase activity (H4-K5 specific) | IDA | molecular_function |
| GO:0043996 | Histone acetyltransferase activity (H4-K8 specific) | IDA | molecular_function |
| GO:0045787 | Positive regulation of cell cycle | TAS | biological_process |
| GO:0046972 | Histone acetyltransferase activity (H4-K16 specific) | IDA | molecular_function |
| GO:0048188 | Set1C/COMPASS complex | IDA | cellular_component |
| GO:0050821 | Protein stabilization | IDA | biological_process |
| GO:0070461 | SAGA-type complex | IDA | cellular_component |
| GO:0070688 | MLL5-L complex | IDA | cellular_component |
| GO:0071339 | MLL1 complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3675036283 | 0.3390612933 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1347669097 |
| GSE13712_SHEAR | Up | 0.1182797217 |
| GSE13712_STATIC | Down | -0.0605716332 |
| GSE19018 | Down | -0.0761905934 |
| GSE19899_A1 | Down | -0.0372609160 |
| GSE19899_A2 | Down | -0.1966947655 |
| PubMed_21979375_A1 | Up | 0.4027104450 |
| PubMed_21979375_A2 | Up | 0.0825436649 |
| GSE35957 | Up | 0.0069832859 |
| GSE36640 | Down | -0.4541011118 |
| GSE54402 | Up | 0.1854242505 |
| GSE9593 | Down | -0.3047383330 |
| GSE43922 | Up | 0.1551594641 |
| GSE24585 | Down | -0.6578201238 |
| GSE37065 | Down | -0.0707691343 |
| GSE28863_A1 | Up | 0.6295228718 |
| GSE28863_A2 | Up | 0.7571771552 |
| GSE28863_A3 | Up | 0.3464192995 |
| GSE28863_A4 | Up | 0.0382193964 |
| GSE48662 | Down | -0.3913473056 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036089 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040355 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041503 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041883 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045650 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046582 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047097 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049708 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23a-3p | MIMAT0000078 | MIRT050444 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052040 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
