HCSGD entry for SERPIND1
1. General information
| Official gene symbol | SERPIND1 |
|---|---|
| Entrez ID | 3053 |
| Gene full name | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 |
| Other gene symbols | D22S673 HC2 HCF2 HCII HLS2 LS2 THPH10 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004866 | Endopeptidase inhibitor activity | TAS | molecular_function |
| GO:0004867 | Serine-type endopeptidase inhibitor activity | IBA | molecular_function |
| GO:0005576 | Extracellular region | NAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006935 | Chemotaxis | IEA | biological_process |
| GO:0007596 | Blood coagulation | IEA | biological_process |
| GO:0008201 | Heparin binding | IEA | molecular_function |
| GO:0010951 | Negative regulation of endopeptidase activity | IBA | biological_process |
| GO:0030162 | Regulation of proteolysis | IBA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000157175 | 0.9881995099 | 0.0137900000 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 2.2471045917 |
| GSE13712_SHEAR | Up | 4.6243947919 |
| GSE13712_STATIC | Up | 4.0505533669 |
| GSE19018 | Down | -0.0453747016 |
| GSE19899_A1 | Up | 0.7054291230 |
| GSE19899_A2 | Up | 5.8925952031 |
| PubMed_21979375_A1 | Up | 4.9293433112 |
| PubMed_21979375_A2 | Up | 5.1362785108 |
| GSE35957 | Down | -0.0661995255 |
| GSE36640 | Up | 1.8222516573 |
| GSE54402 | Up | 3.1224922182 |
| GSE9593 | Up | 0.0365958230 |
| GSE43922 | Up | 1.8428174998 |
| GSE24585 | Up | 0.0356157858 |
| GSE37065 | Up | 0.0454848150 |
| GSE28863_A1 | Down | -0.1676270307 |
| GSE28863_A2 | Down | -0.1984936496 |
| GSE28863_A3 | Up | 0.1334339252 |
| GSE28863_A4 | Up | 0.1593458518 |
| GSE48662 | Down | -0.0068236011 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018769 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22570136 | We crossed C57BL/6J mice with a new wild-derived strain, Pohn, and identified two life span QTL-Ls1 and Ls2 |
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