HCSGD entry for HCCS
1. General information
| Official gene symbol | HCCS |
|---|---|
| Entrez ID | 3052 |
| Gene full name | holocytochrome c synthase |
| Other gene symbols | CCHL MCOPS7 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004408 | Holocytochrome-c synthase activity | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0009887 | Organ morphogenesis | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0055114 | Oxidation-reduction process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0218789636 | 0.2843772045 | 0.3550546125 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6844392146 |
| GSE13712_SHEAR | Up | 0.1548659894 |
| GSE13712_STATIC | Up | 0.3306089730 |
| GSE19018 | Up | 0.0199776506 |
| GSE19899_A1 | Up | 0.2444760813 |
| GSE19899_A2 | Up | 0.7749831789 |
| PubMed_21979375_A1 | Up | 1.6678904419 |
| PubMed_21979375_A2 | Up | 0.7055771192 |
| GSE35957 | Down | -0.0685867646 |
| GSE36640 | Up | 0.5026796397 |
| GSE54402 | Up | 0.4496045250 |
| GSE9593 | Down | -0.1478806853 |
| GSE43922 | Up | 0.6554945952 |
| GSE24585 | Down | -1.3319013397 |
| GSE37065 | Up | 0.1744415006 |
| GSE28863_A1 | Down | -0.5676434702 |
| GSE28863_A2 | Down | -0.3150263251 |
| GSE28863_A3 | Down | -0.0278782098 |
| GSE28863_A4 | Up | 0.1418924151 |
| GSE48662 | Down | -0.5386143221 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020136 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT023250 | Proteomics | Functional MTI (Weak) | 21750653 |
| hsa-miR-148a-3p | MIMAT0000243 | MIRT025988 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT027992 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25278690 | Remarkably, HCCs have been reported in non-cirrhotic livers in a higher proportion of cases in NAFLD patients than in other etiologies |
| 22991213 | In this study, we found that SUV39H1 was frequently up-regulated in human HCCs and was significantly associated with increased Ki67 expression (P < 0 |
| 22080947 | Impaired immune surveillance of pre-malignant senescent hepatocytes results in the development of murine hepatocellular carcinomas (HCCs), thus showing that senescence surveillance is important for tumour suppression in vivo |
| 19522540 | Frozen liver tissues from a retrospective cohort of 75 liver patients (39 HCCs, 20 cirrhosis, and 16 nondiseased subjects) were subjected to proteome-wide expression profiling by 2-DE |
| 19522540 | Conventional RT-PCR was employed to further analyze the abundance of selected biomarker at mRNA level in a separate cohort of 63 plasma samples (35 HCCs, 16 liver cirrhosis, 12 healthy individuals) |
| 17023886 | Nearly all HCCs have telomerase activity and assessments of telomeres and telomerase may be clinically useful |
| 11274643 | A total of 57 frozen liver samples (15 normal liver, 32 chronic hepatitis C, and 10 HCCs) were studied |
| 11274643 | Replicative senescence was considered present in 3 of 15 normal livers (20%), 16 of 32 chronic hepatitis cases (50%), and 6 of 10 HCCs (60%) |
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