HCSGD entry for HBB

1. General information

Official gene symbolHBB
Entrez ID3043
Gene full namehemoglobin, beta
Other gene symbolsCD113t-C beta-globin
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004601Peroxidase activityIDAmolecular_function
GO:0005344Oxygen transporter activityIEA NASmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005833Hemoglobin complexIDA IEA NAS TAScellular_component
GO:0007596Blood coagulationTASbiological_process
GO:0008217Regulation of blood pressureIEAbiological_process
GO:0010942Positive regulation of cell deathIDAbiological_process
GO:0015671Oxygen transportNAS TASbiological_process
GO:0015701Bicarbonate transportTASbiological_process
GO:0019825Oxygen bindingIDA IEAmolecular_function
GO:0020037Heme bindingIEAmolecular_function
GO:0030185Nitric oxide transportNASbiological_process
GO:0030492Hemoglobin bindingIDAmolecular_function
GO:0031720Haptoglobin bindingIDAmolecular_function
GO:0031838Haptoglobin-hemoglobin complexIDAcellular_component
GO:0042542Response to hydrogen peroxideIDAbiological_process
GO:0042744Hydrogen peroxide catabolic processIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045429Positive regulation of nitric oxide biosynthetic processNASbiological_process
GO:0050880Regulation of blood vessel sizeIEAbiological_process
GO:0051291Protein heterooligomerizationIDAbiological_process
GO:0055114Oxidation-reduction processIDAbiological_process
GO:0070293Renal absorptionIMPbiological_process
GO:0071682Endocytic vesicle lumenTAScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.49287130050.44351395460.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1395011294
GSE13712_SHEARUp0.0821031111
GSE13712_STATICDown-0.0300840469
GSE19018Up0.0505170551
GSE19899_A1Up0.0486118815
GSE19899_A2Up0.0172166814
PubMed_21979375_A1Down-0.2995965165
PubMed_21979375_A2Down-0.3440339236
GSE35957Up0.1668830505
GSE36640Up1.6997105319
GSE54402Down-0.4091332358
GSE9593Up0.0491258252
GSE43922Up0.0193407908
GSE24585Up0.0687675561
GSE37065Down-0.1524488083
GSE28863_A1Up0.3879608741
GSE28863_A2Down-0.2061871495
GSE28863_A3Up0.0730612163
GSE28863_A4Down-0.0080394198
GSE48662Up0.0203559567

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Iron DextranDB00893 APRD01053
4-Carboxycinnamic AcidDB02126 EXPT00919
2-[(2-methoxy-5-methylphenoxy)methyl]pyridineDB07427 -
4-[(5-methoxy-2-methylphenoxy)methyl]pyridineDB07428 -
SEBACIC ACIDDB07645 -
2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACIDDB08077 -
2,6-dicarboxynaphthaleneDB08262 -
2-{4-[(3,5-DIMETHYLANILINO)-CARBONYL-METHYL]-PHENOXY}-2-METHYLPROPIONIC ACIDDB08486 -
1,3,5-BENZENETRICARBOXYLIC ACIDDB08632 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-92a-3pMIMAT0000092MIRT049575CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

9141625They also expressed RNA for beta-globin, GATA-1, and NF-E2
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