HCSGD entry for HAS3
1. General information
| Official gene symbol | HAS3 |
|---|---|
| Entrez ID | 3038 |
| Gene full name | hyaluronan synthase 3 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0016021 | Integral component of membrane | TAS | cellular_component |
| GO:0030203 | Glycosaminoglycan metabolic process | TAS | biological_process |
| GO:0030212 | Hyaluronan metabolic process | TAS | biological_process |
| GO:0030213 | Hyaluronan biosynthetic process | IDA IEA TAS | biological_process |
| GO:0036117 | Hyaluranon cable | IDA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045226 | Extracellular polysaccharide biosynthetic process | IEA ISS | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0050501 | Hyaluronan synthase activity | IDA IEA | molecular_function |
| GO:0085029 | Extracellular matrix assembly | IEA ISS | biological_process |
| GO:1900106 | Positive regulation of hyaluranon cable assembly | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5608995251 | 0.0569150944 | 0.9999902473 | 0.4479304335 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1441541621 |
| GSE13712_SHEAR | Up | 0.3519367165 |
| GSE13712_STATIC | Up | 0.9281993991 |
| GSE19018 | Down | -0.0265202042 |
| GSE19899_A1 | Up | 0.1325154541 |
| GSE19899_A2 | Down | -0.1889662831 |
| PubMed_21979375_A1 | Down | -0.2404929637 |
| PubMed_21979375_A2 | Down | -0.1874752674 |
| GSE35957 | Up | 1.2479977551 |
| GSE36640 | Up | 0.0712785718 |
| GSE54402 | Down | -0.1420284228 |
| GSE9593 | Down | -0.3964264001 |
| GSE43922 | Down | -0.0091681043 |
| GSE24585 | Down | -0.1260771350 |
| GSE37065 | Down | -0.0484719012 |
| GSE28863_A1 | Down | -0.5962534427 |
| GSE28863_A2 | Down | -0.9949195515 |
| GSE28863_A3 | Down | -0.0822389466 |
| GSE28863_A4 | Down | -0.1036658107 |
| GSE48662 | Up | 0.1728669138 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024770 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026580 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15610763 | Pyruvate dehydrogenase kinase 3 (Pdk3) and connective tissue growth factor (Ctgf) were up-regulated and hyaluronan synthase 3 (Has3) down-regulated under both conditions |
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