HCSGD entry for HAS2
1. General information
| Official gene symbol | HAS2 |
|---|---|
| Entrez ID | 3037 |
| Gene full name | hyaluronan synthase 2 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001570 | Vasculogenesis | ISS | biological_process |
| GO:0001822 | Kidney development | ISS | biological_process |
| GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
| GO:0008284 | Positive regulation of cell proliferation | IMP | biological_process |
| GO:0030213 | Hyaluronan biosynthetic process | IDA IEA IMP ISS | biological_process |
| GO:0030335 | Positive regulation of cell migration | IMP | biological_process |
| GO:0035810 | Positive regulation of urine volume | ISS | biological_process |
| GO:0036120 | Cellular response to platelet-derived growth factor stimulus | IDA | biological_process |
| GO:0036302 | Atrioventricular canal development | ISS | biological_process |
| GO:0045226 | Extracellular polysaccharide biosynthetic process | ISS | biological_process |
| GO:0050501 | Hyaluronan synthase activity | IMP ISS | molecular_function |
| GO:0060349 | Bone morphogenesis | IEA | biological_process |
| GO:0070295 | Renal water absorption | ISS | biological_process |
| GO:0071347 | Cellular response to interleukin-1 | IEP | biological_process |
| GO:0071356 | Cellular response to tumor necrosis factor | IEP | biological_process |
| GO:0071498 | Cellular response to fluid shear stress | IEP | biological_process |
| GO:0085029 | Extracellular matrix assembly | ISS | biological_process |
| GO:0090500 | Endocardial cushion to mesenchymal transition | ISS | biological_process |
| GO:1900625 | Positive regulation of monocyte aggregation | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2226657574 | 0.0007848600 | 0.9037448574 | 0.0524322335 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1714765919 |
| GSE13712_SHEAR | Down | -0.1114099893 |
| GSE13712_STATIC | Down | -0.2596465696 |
| GSE19018 | Down | -0.4009683031 |
| GSE19899_A1 | Down | -0.0819846609 |
| GSE19899_A2 | Up | 0.7899321814 |
| PubMed_21979375_A1 | Down | -0.4821924054 |
| PubMed_21979375_A2 | Down | -1.5267127844 |
| GSE35957 | Down | -1.2179719802 |
| GSE36640 | Down | -3.9442516541 |
| GSE54402 | Up | 1.4060759116 |
| GSE9593 | Down | -2.7881542599 |
| GSE43922 | Up | 0.0393430315 |
| GSE24585 | Down | -0.4730711023 |
| GSE37065 | Down | -0.4053873444 |
| GSE28863_A1 | Down | -2.0334968948 |
| GSE28863_A2 | Up | 0.5597341319 |
| GSE28863_A3 | Up | 0.3311603552 |
| GSE28863_A4 | Up | 0.7151486760 |
| GSE48662 | Down | -1.6245369408 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-204-5p | MIMAT0000265 | MIRT005828 | Microarray | Functional MTI (Weak) | 21282569 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT035534 | Luciferase reporter assay | Functional MTI | 22871741 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26987798 | Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis |
| 26987798 | We previously demonstrated that over-expression of HAS2 in mesenchymal cells in mice regulates the invasiveness of fibroblasts and promotes severe lung fibrosis |
| 26987798 | We propose that a critical step in resolving fibrosis is the induction of senescence in fibrotic fibroblasts and hyaluronan synthase 2 may regulate this process |
| 26987798 | We found that fibrotic fibroblasts developed the characteristics of replicative senescence in culture and that HAS2 expression was dramatically down-regulated |
| 26987798 | Furthermore, down-regulation of HAS2 initiated and regulated fibroblast senescence through a p27-CDK2-SKP2 pathway |
| 26987798 | Deletion of HAS2 in mouse mesenchymal cells increased the cellular senescence of fibroblasts in bleomycin-induced mouse lung fibrosis in vivo |
| 26987798 | These data suggest that HAS2 may be a critical regulator of the fate of pulmonary fibrosis and we propose a model where over-expression of HAS2 promotes an invasive phenotype resulting in severe fibrosis and down-regulation of HAS2 promotes resolution |
| 26987798 | Targeting HAS2 to induce fibroblast senescence could be an attractive approach to resolve tissue fibrosis |
| 25264594 | Among them, miR-23a-3p was shown to target hyaluronan synthase 2 (HAS2) |
| 25264594 | In addition, siRNA-mediated downregulation of HAS2 and pharmacological inhibition of HA synthesis by 4-methylumbelliferone mimicked the effects of miR-23a-3p |
| 25264594 | In vivo, miR-23a-3p was upregulated and HAS2 was downregulated in the skin of old mice compared with young mice |
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