HCSGD entry for HARS
1. General information
| Official gene symbol | HARS |
|---|---|
| Entrez ID | 3035 |
| Gene full name | histidyl-tRNA synthetase |
| Other gene symbols | HRS USH3B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004812 | Aminoacyl-tRNA ligase activity | IEA | molecular_function |
| GO:0004821 | Histidine-tRNA ligase activity | IEA NAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006412 | Translation | NAS | biological_process |
| GO:0006418 | TRNA aminoacylation for protein translation | IEA TAS | biological_process |
| GO:0006427 | Histidyl-tRNA aminoacylation | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0500150108 | 0.7903940162 | 0.4896391676 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.8164540667 |
| GSE13712_SHEAR | Down | -0.0643859824 |
| GSE13712_STATIC | Up | 0.1814216031 |
| GSE19018 | Down | -0.5159627225 |
| GSE19899_A1 | Up | 0.6119605677 |
| GSE19899_A2 | Up | 0.3939409646 |
| PubMed_21979375_A1 | Up | 0.6144384271 |
| PubMed_21979375_A2 | Up | 0.5298388624 |
| GSE35957 | Down | -0.1470975096 |
| GSE36640 | Down | -0.3259215492 |
| GSE54402 | Up | 0.9904249732 |
| GSE9593 | Down | -0.1814182166 |
| GSE43922 | Up | 0.3377041088 |
| GSE24585 | Down | -0.0317915768 |
| GSE37065 | Down | -0.2233362619 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.2180043281 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT001460 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020182 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028054 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031140 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-342-3p | MIMAT0000753 | MIRT043717 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045675 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047138 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051984 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
