HCSGD entry for ANXA1

1. General information

Official gene symbolANXA1
Entrez ID301
Gene full nameannexin A1
Other gene symbolsANX1 LPC1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001533Cornified envelopeIDAcellular_component
GO:0001780Neutrophil homeostasisIEA IMPbiological_process
GO:0002674Negative regulation of acute inflammatory responseIEAbiological_process
GO:0004859Phospholipase inhibitor activityIEAmolecular_function
GO:0005102Receptor bindingTASmolecular_function
GO:0005198Structural molecule activityIDAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005543Phospholipid bindingTASmolecular_function
GO:0005544Calcium-dependent phospholipid bindingIDA IEAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDA TAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005929CiliumIEAcellular_component
GO:0006928Cellular component movementTASbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007166Cell surface receptor signaling pathwayIEAbiological_process
GO:0010165Response to X-rayIEAbiological_process
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0018149Peptide cross-linkingIDAbiological_process
GO:0019834Phospholipase A2 inhibitor activityIDA IEAmolecular_function
GO:0030073Insulin secretionIEAbiological_process
GO:0030216Keratinocyte differentiationIDAbiological_process
GO:0030674Protein binding, bridgingIDAmolecular_function
GO:0031018Endocrine pancreas developmentIEAbiological_process
GO:0031340Positive regulation of vesicle fusionIDAbiological_process
GO:0031394Positive regulation of prostaglandin biosynthetic processIEAbiological_process
GO:0031966Mitochondrial membraneIEAcellular_component
GO:0032355Response to estradiolIEAbiological_process
GO:0033031Positive regulation of neutrophil apoptotic processIEAbiological_process
GO:0042063GliogenesisIEAbiological_process
GO:0042127Regulation of cell proliferationIEAbiological_process
GO:0042383SarcolemmaIEAcellular_component
GO:0042493Response to drugIEAbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0043066Negative regulation of apoptotic processIEA TASbiological_process
GO:0043086Negative regulation of catalytic activityIDAbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0046632Alpha-beta T cell differentiationIEA ISSbiological_process
GO:0050482Arachidonic acid secretionIEAbiological_process
GO:0050709Negative regulation of protein secretionIEAbiological_process
GO:0050790Regulation of catalytic activityIDAbiological_process
GO:0060206Estrous cycle phaseIEAbiological_process
GO:0070062Extracellular vesicular exosomeIDAcellular_component
GO:0070301Cellular response to hydrogen peroxideIEAbiological_process
GO:0070365Hepatocyte differentiationIEAbiological_process
GO:0070555Response to interleukin-1IEAbiological_process
GO:0071385Cellular response to glucocorticoid stimulusIDA IEAbiological_process
GO:0097350Neutrophil clearanceIMPbiological_process
GO:1900087Positive regulation of G1/S transition of mitotic cell cycleIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.22055617190.03094064060.90191752290.3311875101

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1431287229
GSE13712_SHEARUp0.7789567607
GSE13712_STATICUp0.1161329113
GSE19018Up0.6938493011
GSE19899_A1Down-0.0650623024
GSE19899_A2Down-0.3132436944
PubMed_21979375_A1Down-0.3923418589
PubMed_21979375_A2Down-0.1279040967
GSE35957Down-0.3064531739
GSE36640Up0.4919147733
GSE54402Down-0.0317018869
GSE9593Up0.1129058440
GSE43922Down-0.0708127846
GSE24585Down-1.9197108046
GSE37065Up0.0600940598
GSE28863_A1Down-0.1153032888
GSE28863_A2Down-0.4046122988
GSE28863_A3Down-0.5804246366
GSE28863_A4Up0.6129419035
GSE48662Down-0.2702391229

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AmcinonideDB00288 APRD00788

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-196a-5pMIMAT0000226MIRT000709qRT-PCR//Luciferase reporter assay//Western blot//Reporter assay;OtherFunctional MTI18663355
hsa-miR-335-5pMIMAT0000765MIRT018638MicroarrayFunctional MTI (Weak)18185580
hsa-miR-30a-5pMIMAT0000087MIRT028650ProteomicsFunctional MTI (Weak)18668040
hsa-miR-26b-5pMIMAT0000083MIRT030065MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-196a-5pMIMAT0000226NAhsa-miR-196a{Western blot}{overexpression by miRNA mimics tranfection}18663355
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21932444A total of 13 proteins were up-regulated in CTP, including apoptosis-related cathepsin D (CD), annexin A1 and heat shock protein 27 (HSP 27), and seven proteins were down-regulated in CTP, including prohibitin (PHB)
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