HCSGD entry for GZMA
1. General information
| Official gene symbol | GZMA |
|---|---|
| Entrez ID | 3001 |
| Gene full name | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) |
| Other gene symbols | CTLA3 HFSP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001772 | Immunological synapse | TAS | cellular_component |
| GO:0004252 | Serine-type endopeptidase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0019835 | Cytolysis | IEA | biological_process |
| GO:0032078 | Negative regulation of endodeoxyribonuclease activity | IDA | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0043065 | Positive regulation of apoptotic process | IDA | biological_process |
| GO:0043392 | Negative regulation of DNA binding | IDA | biological_process |
| GO:0051354 | Negative regulation of oxidoreductase activity | IDA | biological_process |
| GO:0051603 | Proteolysis involved in cellular protein catabolic process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7606842407 | 0.4458903917 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0227014665 |
| GSE13712_SHEAR | Down | -0.1312552199 |
| GSE13712_STATIC | Down | -0.0217572629 |
| GSE19018 | Down | -0.0615489290 |
| GSE19899_A1 | Up | 0.0422490792 |
| GSE19899_A2 | Down | -0.0073868007 |
| PubMed_21979375_A1 | Up | 0.1552889046 |
| PubMed_21979375_A2 | Down | -0.0774596458 |
| GSE35957 | Up | 0.0059642961 |
| GSE36640 | Down | -0.0761353898 |
| GSE54402 | Up | 0.6305100735 |
| GSE9593 | Down | -0.0382001747 |
| GSE43922 | Up | 0.0135543425 |
| GSE24585 | Down | -0.1479102063 |
| GSE37065 | Up | 0.0158514879 |
| GSE28863_A1 | Down | -0.0547058448 |
| GSE28863_A2 | Down | -0.3026508253 |
| GSE28863_A3 | Up | 0.2734303811 |
| GSE28863_A4 | Down | -0.1711378231 |
| GSE48662 | Down | -0.0168983746 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26577046 | Overexpression of constitutively active FOXO1 in PR-A-expressing cells conferred robust ligand-dependent upregulation of the PR-B target genes GZMA, IGFBP1, and p21, and induced cellular senescence |
| 16204645 | As Eomes null mice are not viable, real-time polymerase chain reaction comparisons between C57Bl/6J (B6) and alymphoid (Rag2(0/0)gammac0/0) mice were used to assess uNK cell expression of T-bet, Eomes, and the target genes IFN-gamma, granzyme A, and perforin |
| 16204645 | In uNK cells, transcripts for T-bet, Eomes, and IFN-gamma were most abundant in mature stage cells, and transcripts for granzyme A and perforin were lower at this stage than in immature or senescent cells |
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