HCSGD entry for ERO1L
1. General information
| Official gene symbol | ERO1L |
|---|---|
| Entrez ID | 30001 |
| Gene full name | ERO1-like (S. cerevisiae) |
| Other gene symbols | ERO1-alpha ERO1A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003756 | Protein disulfide isomerase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IDA IEA | cellular_component |
| GO:0005788 | Endoplasmic reticulum lumen | TAS | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0006457 | Protein folding | TAS | biological_process |
| GO:0006464 | Cellular protein modification process | TAS | biological_process |
| GO:0009266 | Response to temperature stimulus | TAS | biological_process |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016491 | Oxidoreductase activity | IDA | molecular_function |
| GO:0016671 | Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor | IEA | molecular_function |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | IEA | biological_process |
| GO:0034976 | Response to endoplasmic reticulum stress | ISS | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | TAS | cellular_component |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0050873 | Brown fat cell differentiation | IEA | biological_process |
| GO:0051085 | Chaperone mediated protein folding requiring cofactor | IDA | biological_process |
| GO:0051209 | Release of sequestered calcium ion into cytosol | IEA ISS | biological_process |
| GO:0070059 | Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0130765928 | 0.3292192356 | 0.2848953681 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.9450768417 |
| GSE13712_SHEAR | Up | 0.6181765322 |
| GSE13712_STATIC | Up | 0.4733317662 |
| GSE19018 | Up | 2.6693857215 |
| GSE19899_A1 | Up | 0.2708122161 |
| GSE19899_A2 | Up | 0.2972237702 |
| PubMed_21979375_A1 | Up | 0.1297659751 |
| PubMed_21979375_A2 | Up | 0.5200371687 |
| GSE35957 | Down | -0.9162452549 |
| GSE36640 | Down | -0.8631683542 |
| GSE54402 | Up | 0.1457534795 |
| GSE9593 | Up | 0.5467869883 |
| GSE43922 | Up | 0.1883525024 |
| GSE24585 | Down | -0.2828414074 |
| GSE37065 | Up | 0.3159302170 |
| GSE28863_A1 | Down | -0.0277641813 |
| GSE28863_A2 | Up | 0.8303381477 |
| GSE28863_A3 | Down | -0.4867729906 |
| GSE28863_A4 | Up | 0.0199670286 |
| GSE48662 | Down | -0.0466643936 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT027850 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032494 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038460 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044365 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-182-5p | MIMAT0000259 | MIRT047216 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
