HCSGD entry for GLTSCR2
1. General information
| Official gene symbol | GLTSCR2 |
|---|---|
| Entrez ID | 29997 |
| Gene full name | glioma tumor suppressor candidate region gene 2 |
| Other gene symbols | PICT-1 PICT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0005622 | Intracellular | NAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0008150 | Biological_process | ND | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6919299115 | 0.3359099502 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1398137612 |
| GSE13712_SHEAR | Down | -0.2587154415 |
| GSE13712_STATIC | Down | -0.1882637392 |
| GSE19018 | Up | 0.2694102234 |
| GSE19899_A1 | Down | -0.0119784924 |
| GSE19899_A2 | Up | 0.3431299644 |
| PubMed_21979375_A1 | Up | 0.2126846994 |
| PubMed_21979375_A2 | Down | -0.2893549708 |
| GSE35957 | Down | -0.0616345526 |
| GSE36640 | Down | -0.0403689859 |
| GSE54402 | Down | -0.1517950495 |
| GSE9593 | Down | -0.0674198886 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.1030354729 |
| GSE28863_A2 | Down | -0.2034514065 |
| GSE28863_A3 | Up | 0.3771309097 |
| GSE28863_A4 | Down | -0.0038141959 |
| GSE48662 | Up | 0.2729195026 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023701 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031594 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032357 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT045884 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27357325 | Role of GLTSCR2 in the regulation of telomerase activity and chromosome stability |
| 27357325 | In the present study, the role of glioma tumor-suppressor candidate region gene 2 (GLTSCR2) in telomerase regulation was analyzed |
| 27357325 | The results revealed that overexpression of GLTSCR2 significantly increased telomerase activity in the cancer and normal cell lines |
| 27357325 | In luciferase assays, the hTERT promoter was activated by GLTSCR2 |
| 27357325 | Knockdown of GLTSCR2 led to the downregulation of telomerase activity, abnormal nuclear morphology as a marker of chromosome instability, significant suppression of growth rate, alterations in cellular morphology and, eventually, cellular senescence |
| 27357325 | Taken together, the results of the present study suggested that GLTSCR2 is crucially involved in the positive regulation of telomerase and chromosome stability |
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