HCSGD entry for ANAPC4

1. General information

Official gene symbolANAPC4
Entrez ID29945
Gene full nameanaphase promoting complex subunit 4
Other gene symbolsAPC4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000090Mitotic anaphaseTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0004842Ubiquitin-protein ligase activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005680Anaphase-promoting complexIDA IEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006511Ubiquitin-dependent protein catabolic processTASbiological_process
GO:0007067MitosisIEAbiological_process
GO:0007094Mitotic spindle assembly checkpointTASbiological_process
GO:0019903Protein phosphatase bindingIPImolecular_function
GO:0030071Regulation of mitotic metaphase/anaphase transitionIEAbiological_process
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processIEA TASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0070979Protein K11-linked ubiquitinationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.98721755250.00954579230.99999024730.1935707242

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1007141111
GSE13712_SHEARDown-0.0015560923
GSE13712_STATICDown-0.0465346125
GSE19018Down-0.9089097041
GSE19899_A1Down-0.4343608797
GSE19899_A2Down-0.3983345661
PubMed_21979375_A1Up0.3009110541
PubMed_21979375_A2Down-0.4214751565
GSE35957Down-0.1947691304
GSE36640Down-0.3091212430
GSE54402Down-0.1223423532
GSE9593Down-0.2691315501
GSE43922Down-0.0996235060
GSE24585Down-0.2685370929
GSE37065Up0.0659646729
GSE28863_A1Down-0.0515020667
GSE28863_A2Up0.0125915922
GSE28863_A3Down-0.8856750459
GSE28863_A4Down-0.4222289465
GSE48662Down-0.3684242530

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022718Proteomics;MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.