HCSGD entry for SEC61A1
1. General information
| Official gene symbol | SEC61A1 |
|---|---|
| Entrez ID | 29927 |
| Gene full name | Sec61 alpha 1 subunit (S. cerevisiae) |
| Other gene symbols | HSEC61 SEC61 SEC61A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002474 | Antigen processing and presentation of peptide antigen via MHC class I | TAS | biological_process |
| GO:0002479 | Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005791 | Rough endoplasmic reticulum | IEA | cellular_component |
| GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | IMP | biological_process |
| GO:0006620 | Posttranslational protein targeting to membrane | IMP | biological_process |
| GO:0007029 | Endoplasmic reticulum organization | IMP | biological_process |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0016020 | Membrane | IDA IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016049 | Cell growth | IMP | biological_process |
| GO:0030176 | Integral component of endoplasmic reticulum membrane | ISS | cellular_component |
| GO:0034341 | Response to interferon-gamma | IEA | biological_process |
| GO:0042590 | Antigen processing and presentation of exogenous peptide antigen via MHC class I | TAS | biological_process |
| GO:0043022 | Ribosome binding | IEA ISS | molecular_function |
| GO:0045047 | Protein targeting to ER | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3324383306 | 0.4167990274 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2388909143 |
| GSE13712_SHEAR | Up | 0.2053037861 |
| GSE13712_STATIC | Up | 0.1563112821 |
| GSE19018 | Up | 0.2436391955 |
| GSE19899_A1 | Down | -0.5182818805 |
| GSE19899_A2 | Up | 0.1068574715 |
| PubMed_21979375_A1 | Up | 0.1801884068 |
| PubMed_21979375_A2 | Down | -0.8821049815 |
| GSE35957 | Up | 0.0363999649 |
| GSE36640 | Up | 0.4826221615 |
| GSE54402 | Up | 0.0204925437 |
| GSE9593 | Up | 0.6431328810 |
| GSE43922 | Up | 0.0410307492 |
| GSE24585 | Down | -0.0349210414 |
| GSE37065 | Down | -0.0324387585 |
| GSE28863_A1 | Down | -0.1853751896 |
| GSE28863_A2 | Up | 0.1039016694 |
| GSE28863_A3 | Down | -0.1985506965 |
| GSE28863_A4 | Down | -0.1555009110 |
| GSE48662 | Down | -0.1179959104 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016511 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018417 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT021794 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT022079 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-1 | MIMAT0000416 | MIRT023915 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031834 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040296 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
