HCSGD entry for STRN4
1. General information
| Official gene symbol | STRN4 |
|---|---|
| Entrez ID | 29888 |
| Gene full name | striatin, calmodulin binding protein 4 |
| Other gene symbols | ZIN zinedin |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000159 | Protein phosphatase type 2A complex | IDA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005516 | Calmodulin binding | NAS | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0008150 | Biological_process | ND | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0019904 | Protein domain specific binding | IEA | molecular_function |
| GO:0032403 | Protein complex binding | IDA IEA | molecular_function |
| GO:0043197 | Dendritic spine | IEA | cellular_component |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0051721 | Protein phosphatase 2A binding | IDA | molecular_function |
| GO:0070016 | Armadillo repeat domain binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2330489229 | 0.3608459937 | 0.9167691365 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1105219534 |
| GSE13712_SHEAR | Down | -0.6121051313 |
| GSE13712_STATIC | Down | -0.2409137882 |
| GSE19018 | Down | -0.1117160628 |
| GSE19899_A1 | Up | 0.0039379506 |
| GSE19899_A2 | Up | 0.3418522966 |
| PubMed_21979375_A1 | Up | 0.5529804543 |
| PubMed_21979375_A2 | Up | 1.6484364315 |
| GSE35957 | Down | -0.4092269231 |
| GSE36640 | Up | 0.0955172012 |
| GSE54402 | Up | 0.1286582315 |
| GSE9593 | Down | -0.2044714712 |
| GSE43922 | Up | 0.0045236765 |
| GSE24585 | Down | -0.0076720985 |
| GSE37065 | Down | -0.2185040703 |
| GSE28863_A1 | Up | 0.0482884864 |
| GSE28863_A2 | Down | -0.0147619075 |
| GSE28863_A3 | Up | 0.4151409568 |
| GSE28863_A4 | Down | -0.1236409253 |
| GSE48662 | Up | 0.1057437003 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040848 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22665485 | STRN4 (Zinedin) is a regulatory subunit of protein phosphatase 2A (PP2A) and was recently shown to be a component of a novel protein complex called striatin-interacting phosphatase and kinase (STRIPAK) |
| 22665485 | Mass spectrometry analysis showed that MINK1 was a component of STRIPAK and that MINK1 directly interacted with STRN4 |
| 22665485 | In addition, STRN4 reduced MINK1 activity in the presence of catalytic and structural subunits of PP2A |
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